Scientist II/Senior Scientist, Medicinal Chemistry

1 month ago

Menlo Park, United States AN2 Therapeutics Full time

AN2 Therapeutics, Inc. is a biopharmaceutical company focused on discovering and developing novel small molecule therapeutics derived from our boron chemistry platform. We have a pipeline of boron-based compounds in development for Chagas disease, NTM, and melioidosis, along with early-stage programs focused on targets in infectious diseases and oncology. We also have both an obligation and a strong desire to combine our drug discovery and development expertise with resources available from public and private organizations to address high unmet needs in global health. We believe our company thrives when all employees share this mission.


AN2 is seeking a Scientist or Senior Scientist, Medicinal Chemistry with industrial drug discovery experience. This individual will play an essential role in cross-functional teams and will be responsible for a range of activities. This position is not anticipated to involve direct laboratory work and will report to the Senior Director, Medicinal Chemistry.


Responsibilities:

  • Playing an instrumental medicinal chemistry role at AN2, including facilitating associated outsourcing, cheminformatics and logistic activities.
  • Working collaboratively with internal stakeholder functions such as Biology, Project Management, Clinical, Legal and Regulatory as well as external collaborators and funders.
  • Ensuring research plans are executed in a timely and professional manner that aligned with AN2's project goals and timelines.
  • Designing compounds using medicinal chemistry first principals, CGDD and synthetic tractability to address series shortcomings and progress AN2 discovery projects.
  • Working with the project team and more senior Medicinal Chemists to prioritize compounds for synthesis and communicating with chemistry CROs.
  • Solving complex scientific challenges, such as troubleshooting novel boron-containing compound syntheses.
  • Reviewing analytical results to ensure high-quality compounds are delivered for AN2 discovery projects and compound collection.
  • Coordinating logistics with Biology and collaborators to ensure timely transfer of compounds and reduced cycle times.
  • Working with project team to identify compounds for inclusion in vitro DMPK assays and coordinating the delivery and testing of those compounds.
  • Ensuring timely and accurate database updating for delivered compounds and DMPK results.
  • Supporting AN2 Development activities, as needed, such as logistic support and standard production at a chemistry CRO.
  • Working with colleagues and senior management to apply for funding opportunities to support growth of early-stage research in-line with AN2’s vision. Actively participating in identifying new funding and programmatic opportunities.
  • Regularly providing research project updates for discovery research activities.
  • Writing sections of grant applications, progress reports, patent applications and publications.
  • Identifying and implementing systems and tools to improve R&D operations, including software and best practices.


Qualifications and Experience:

  • B.Sc. or M.Sc. with a minimum of 6 years experience or a Ph.D. in organic or medicinal chemistry with at least 2-5 years of medicinal chemistry experience, preferably in biotech and pharma.
  • Team oriented with a track record of working on multi-disciplinary teams and pitching in however necessary to progress the discovery projects.
  • A strong knowledge of synthetic organic chemistry is mandatory and experience with boron chemistry is highly desirable.
  • Good understanding of medicinal chemistry concepts, including knowledge of pharmacokinetic, pharmacodynamic and physicochemical principles as applied to small molecule drug discovery.
  • Experience working with CROs, including chemistry and DMPK, to deliver compounds and results is preferred.
  • Proficiency with compound library database and visualization software is desirable.
  • Prior experience overseeing shipping of compounds, including internationally, is ideal.
  • Ability to manage budgets, preparing RFPs, reviewing and approving work orders, and liaising with legal to secure MSA, MTA, CDA and other agreements.
  • Excellent technical writing, oral, presentation, and interpersonal communication skills.
  • Possess high integrity and impeccable attention to detail.
  • Fluent in the Microsoft platform, including Office & SharePoint, and PDF publication & editing software such as Adobe Acrobat.
  • Capability to independently generating progress reports, updates and quality experimental procedures is required.
  • Experience supporting grant applications, patent applications, and manuscripts is valuable.
  • Must be flexible and able to multitask, prioritize, meet deadlines in a fast-paced environment, and be adaptable to setbacks. Exceptional problem-solving skills.
  • Self motivated with ability to work remotely with internal colleagues and external collaborators and vendors.
  • Some travel, is anticipated (

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