Scientist II/Senior Scientist, Medicinal Chemistry

3 weeks ago

menlo, United States AN2 Therapeutics Full time

AN2 Therapeutics, Inc. is a biopharmaceutical company focused on discovering and developing novel small molecule therapeutics derived from our boron chemistry platform. We have a pipeline of boron-based compounds in development for Chagas disease, NTM, and melioidosis, along with early-stage programs focused on targets in infectious diseases and oncology. We also have both an obligation and a strong desire to combine our drug discovery and development expertise with resources available from public and private organizations to address high unmet needs in global health. We believe our company thrives when all employees share this mission.


AN2 is seeking a Scientist or Senior Scientist, Medicinal Chemistry with industrial drug discovery experience. This individual will play an essential role in cross-functional teams and will be responsible for a range of activities. This position is not anticipated to involve direct laboratory work and will report to the Senior Director, Medicinal Chemistry.


Responsibilities:

  • Playing an instrumental medicinal chemistry role at AN2, including facilitating associated outsourcing, cheminformatics and logistic activities.
  • Working collaboratively with internal stakeholder functions such as Biology, Project Management, Clinical, Legal and Regulatory as well as external collaborators and funders.
  • Ensuring research plans are executed in a timely and professional manner that aligned with AN2's project goals and timelines.
  • Designing compounds using medicinal chemistry first principals, CGDD and synthetic tractability to address series shortcomings and progress AN2 discovery projects.
  • Working with the project team and more senior Medicinal Chemists to prioritize compounds for synthesis and communicating with chemistry CROs.
  • Solving complex scientific challenges, such as troubleshooting novel boron-containing compound syntheses.
  • Reviewing analytical results to ensure high-quality compounds are delivered for AN2 discovery projects and compound collection.
  • Coordinating logistics with Biology and collaborators to ensure timely transfer of compounds and reduced cycle times.
  • Working with project team to identify compounds for inclusion in vitro DMPK assays and coordinating the delivery and testing of those compounds.
  • Ensuring timely and accurate database updating for delivered compounds and DMPK results.
  • Supporting AN2 Development activities, as needed, such as logistic support and standard production at a chemistry CRO.
  • Working with colleagues and senior management to apply for funding opportunities to support growth of early-stage research in-line with AN2’s vision. Actively participating in identifying new funding and programmatic opportunities.
  • Regularly providing research project updates for discovery research activities.
  • Writing sections of grant applications, progress reports, patent applications and publications.
  • Identifying and implementing systems and tools to improve R&D operations, including software and best practices.


Qualifications and Experience:

  • B.Sc. or M.Sc. with a minimum of 6 years experience or a Ph.D. in organic or medicinal chemistry with at least 2-5 years of medicinal chemistry experience, preferably in biotech and pharma.
  • Team oriented with a track record of working on multi-disciplinary teams and pitching in however necessary to progress the discovery projects.
  • A strong knowledge of synthetic organic chemistry is mandatory and experience with boron chemistry is highly desirable.
  • Good understanding of medicinal chemistry concepts, including knowledge of pharmacokinetic, pharmacodynamic and physicochemical principles as applied to small molecule drug discovery.
  • Experience working with CROs, including chemistry and DMPK, to deliver compounds and results is preferred.
  • Proficiency with compound library database and visualization software is desirable.
  • Prior experience overseeing shipping of compounds, including internationally, is ideal.
  • Ability to manage budgets, preparing RFPs, reviewing and approving work orders, and liaising with legal to secure MSA, MTA, CDA and other agreements.
  • Excellent technical writing, oral, presentation, and interpersonal communication skills.
  • Possess high integrity and impeccable attention to detail.
  • Fluent in the Microsoft platform, including Office & SharePoint, and PDF publication & editing software such as Adobe Acrobat.
  • Capability to independently generating progress reports, updates and quality experimental procedures is required.
  • Experience supporting grant applications, patent applications, and manuscripts is valuable.
  • Must be flexible and able to multitask, prioritize, meet deadlines in a fast-paced environment, and be adaptable to setbacks. Exceptional problem-solving skills.
  • Self motivated with ability to work remotely with internal colleagues and external collaborators and vendors.
  • Some travel, is anticipated (

  • Scientist II/Senior Scientist, Medicinal Chemistry

    4 weeks ago

    menlo, United States AN2 Therapeutics Full time

    AN2 Therapeutics, Inc. is a biopharmaceutical company focused on discovering and developing novel small molecule therapeutics derived from our boron chemistry platform. We have a pipeline of boron-based compounds in development for Chagas disease, NTM, and melioidosis, along with early-stage programs focused on targets in infectious diseases and oncology. We...

  • Scientist II/Senior Scientist, Medicinal Chemistry

    4 weeks ago

    Menlo Park, United States AN2 Therapeutics Full time

    AN2 Therapeutics, Inc. is a biopharmaceutical company focused on discovering and developing novel small molecule therapeutics derived from our boron chemistry platform. We have a pipeline of boron-based compounds in development for Chagas disease, NTM, and melioidosis, along with early-stage programs focused on targets in infectious diseases and oncology. We...

  • Scientist II, Chemistry

    5 months ago

    Menlo Park, United States ReCode Therapeutics Full time

    Who We Are: ReCode Therapeutics is a clinical-stage genetic medicines company using precision delivery to power the next wave of mRNA and gene correction therapeutics. ReCode’s proprietary Selective Organ Targeting (SORT) lipid nanoparticle (LNP) platform enables highly precise and targeted delivery of genetic medicines directly to the organs, tissues and...

  • Data Scientist

    2 weeks ago

    Menlo Park, United States Diagnose Early Holdings, Inc. Full time

    About Diagnose Early Diagnose Early is making non-invasive breath testing a mainstream technology. Our mission right now is to use toxin testing and fitness monitoring to help our users detect health risks early. Our long-term vision is to use the data we collect to diagnose health conditions early. To achieve this, we have assembled a truly world-class team...

  • Senior Clinical Scientist

    4 weeks ago

    Menlo Park, California, United States GE Healthcare Full time

    Senior Clinical Scientist - Advanced Imaging ExpertAt GE Healthcare, we're committed to improving lives and advancing the field of healthcare through innovative technology and solutions. We're seeking a highly skilled and experienced Senior Clinical Scientist to join our team and contribute to the development and implementation of cutting-edge imaging...

  • Battery Engineer/Scientist

    4 weeks ago

    Menlo Park, California, United States Exponent Full time

    About ExponentWe are a leading engineering and scientific consulting firm that solves complex challenges for our clients. Our team of experts has the depth and breadth of expertise to tackle unique, unprecedented, and urgent challenges.We are committed to engaging multidisciplinary teams of science, engineering, and regulatory experts to empower our clients...

  • Computer Scientist

    4 weeks ago

    Menlo Park, California, United States Exponent Full time

    Job Title: Computer ScientistAbout the Role:We are seeking a skilled Computer Scientist to join our Electrical Engineering and Computer Science Practice in Menlo Park, CA. As a Computer Scientist, you will work with our team to help clients solve complex technical problems in various domains, including patent litigation, automobile failure analysis, and...

  • Research Scientist, Language Model

    4 weeks ago

    Menlo Park, California, United States META Full time

    Research Scientist, Language ModelWe are seeking a highly skilled Research Scientist to join our Large Language Model (LLM) Research team at Meta. As a Research Scientist, you will design and develop state-of-the-art LLMs, pushing the boundaries of natural language processing and generative AI.Key Responsibilities: Design and implement novel methods for...

  • Chemist/Polymer Scientist

    2 weeks ago

    Menlo Park, United States Exponent Full time

    Chemist/Polymer Scientist (Ph.D.)ID: 2024-1811Location: US-CA-Menlo ParkPractice: Polymer Science and Materials ChemistryPosition Type: Full-timePosted Salary Range: USD $120,000.00 - USD $155,000.00 /Yr.About ExponentExponent is the only premium engineering and scientific consulting firm with the depth and breadth of expertise to solve our clients' most...

  • Scientist, Quality Control Specialist

    1 month ago

    Menlo Park, California, United States CSBio Full time

    Job Title: Scientist, Quality Control SpecialistCSBio is a leading contract manufacturing organization specializing in peptide production. With a rich history dating back to 1993, we have established ourselves as a trusted partner for research organizations and pharmaceutical companies worldwide.Job Summary:We are seeking a highly skilled Scientist, Quality...

  • Senior Bioinformatics Scientist

    4 weeks ago

    Menlo Park, California, United States BillionToOne Full time

    Unlock the Power of Molecular DiagnosticsBillionToOne is a pioneering company in the field of molecular diagnostics, dedicated to developing innovative tests that revolutionize disease detection. As a Senior Bioinformatics Scientist, you will play a crucial role in creating computational tools and analyzing groundbreaking molecular diagnostics data.Our team...

  • Data Scientist, Finance

    4 weeks ago

    Menlo Park, California, United States META Full time

    Job Title: Data Scientist, FinanceMeta is seeking a highly skilled Data Scientist to join our Finance team. As a Data Scientist, you will be responsible for analyzing and modeling ROI of Meta's infra capacity investments and decisions, understanding how leading-edge AI technologies are impacting our complex ads ecosystem, and developing actionable insights...

  • Data Scientist, Finance

    3 weeks ago

    Menlo Park, United States META Full time

    Summary: Meta is seeking a highly quantitative, analytical and motivated data scientist for the Finance Data Science team. The Finance DS team has a unique bird's-eye view of Meta's world class advertising business and is positioned at the center of some of the most important strategic decisions for the company. The team is responsible for deeply...

  • Clinical Laboratory Scientist

    4 weeks ago

    Menlo Park, California, United States BillionToOne Full time

    BillionToOne is a pioneering molecular diagnostics company dedicated to developing innovative diagnostic tests that are accessible to all. We are seeking a highly skilled Clinical Laboratory Scientist to join our team and contribute to the end-to-end processing of cancer blood samples in a high-complexity, high-growth CLIA setting.The ideal candidate will...

  • Data Scientist, Finance

    4 weeks ago

    Menlo Park, California, United States META Full time

    Job Summary:Meta is seeking a highly skilled Data Scientist to join the Finance Data Science team. As a key member of the team, you will be responsible for analyzing and modeling ROI of Meta's infra capacity investments and decisions, understanding how leading-edge AI technologies are impacting our complex ads ecosystem, and developing actionable insights to...

  • Data Scientist, Finance

    1 week ago

    Menlo Park, United States META Full time

    Summary: Meta is seeking a highly quantitative, analytical and motivated data scientist for the Finance Data Science team. The Finance DS team has a unique bird's-eye view of Meta's world class advertising business and is positioned at the center of some of the most important strategic decisions for the company. The team is responsible for deeply...

  • Research Scientist Intern, Perception

    4 weeks ago

    Menlo Park, California, United States META Full time

    Research Scientist Intern, PerceptionMeta is seeking a Research Scientist Intern to join the Fundamental AI Research (FAIR) Perception teams. As a Research Scientist Intern, you will have the opportunity to make core algorithmic advances and apply your ideas at an unprecedented scale.ResponsibilitiesPerform research that enables learning the semantics of...

  • Research Scientist Intern, Optimization, Privacy and Inference

    4 weeks ago

    Menlo Park, California, United States META Full time

    Research Scientist Intern, Optimization, Privacy and InferenceMeta is seeking a highly motivated and skilled Research Scientist Intern to join our Central Applied Science team. As a Research Scientist Intern, you will work on cutting-edge research projects that drive real-world impact across Meta's products and infrastructure.ResponsibilitiesApply scientific...

  • Research Scientist Intern, Monetization Computer Vision

    4 weeks ago

    Menlo Park, California, United States META Full time

    Research Scientist Intern, Monetization Computer VisionMeta is seeking a Research Scientist Intern to join the Monetization Generative AI team. As a research intern, you will have the opportunity to make core algorithmic advances and apply your ideas at an unprecedented scale.ResponsibilitiesPerform research to advance the science and technology of...

  • Senior Data Scientist, Brokerage

    1 week ago

    Menlo Park, United States Robinhood Full time

    About the team + role Brokerage products are the bread and butter of Robinhood. The brokerage team is a fast-paced, dynamic, and innovative team. As a member of this cross-functional group, you will collaborate closely with partners in product, operations, and engineering to unlock the potential of our data and shape the future of the brokerage...