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Scientist I, Functional Genomics

4 months ago

San Diego, United States Light Horse Therapeutics Full time

Light Horse Therapeutics is a small molecule drug discovery company based in San Diego, employing tools from chemical and computational biology, in conjunction with precision genome editing methods to identify functional/ ligandable sites on high value oncology protein targets for therapeutic intervention. Light Horse therapeutics was founded by leading academics Brian Liau (Harvard), Ben Cravatt (Scripps) and Nathanael Gray (Stanford) with initial financial backing from Versant Ventures and Mubadala Capital.


Light Horse Therapeutics is seeking a talented, motivated, and creative scientist to join the Functional Genomics Group. Reporting to the Senior Director of Functional Genomics, the candidate will contribute to the design, execution, and analysis of CRISPR-based gene editing screens to study novel oncology targets. They will also perform mechanistic experiments to characterize these targets and the impact of various mutations on their function.


Job Description:

  • Design and execute CRISPR-based mutagenesis screens using state-of-the-art technologies
  • Design, execute and analyze target and site validation studies in disease-relevant preclinical models
  • Develop new CRISPR screening formats and new cell-based assays
  • Stay abreast of the literature and interact with academic experts
  • Work closely with computational biology for the design and analysis of CRISPR screens
  • Position mostly requires benchwork responsibilities
  • Present results regularly at team meetings
  • Perform diligent and timely note-keeping and work process tracking
  • Communicate science and strategy effectively in internal meetings and prepare written reports of data and literature analyses


Required Qualifications:

  • PhD in a biological science
  • Proficiency in mammalian cell line culture, especially large-scale projects
  • Proficiency in standard molecular biology techniques, including RNA and DNA preparation, analysis of proteins by immunoprecipitation and western blotting, mammalian cell line transfection
  • Track record of being able to work independently and to create new workflows
  • Excellent technical laboratory skills
  • Excellent written and oral communication skills
  • Attention to details in documenting, executing, and analyzing experiments
  • Flexibility and eagerness to tackle new tasks and challenges, and meet aggressive timelines
  • Ability to work closely with team members


Preferred Qualifications

  • Experience with large scale functional genomics experiments, including CRISPR-Cas9 mutagenesis screens
  • Experience with lentivirus production, infection, and selection
  • Experience constructing next generation sequencing libraries
  • Experience with state-of-the-art instrumentation including, plate readers, flow cytometers, incucyte, epifluorescence microscopes
  • Familiarity with electronic notebook platforms such as Benchlings


We offer a competitive total compensation package, as well as working in a supportive team environment. The anticipated salary range for candidates who will work in San Diego, CA is $98,000 to $140,000. The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience within the job, type and length of experience within the industry, education, etc.