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Research Associate
3 months ago
We are seeking a candidate to be part of a team focused on non-viral vehicle formulation and characterization in the drug formulation group. The candidate will work with a multidisciplinary team of scientists and be engaged in targeted non-viral formulation development and optimization.
Duties:
- Formulation and characterization of lipid nanoparticles for platform build and project support
- Design and execute formulation trials, analytical testing and evaluate stability data to finalize formulation composition for RNA/gene-based therapies
- Synthesize and develop nanoparticle-based formulations for various therapeutic areas.
- Characterization of nanoparticle-based formulation with analytical method, bio-assays, molecular biology methods, spectroscopy, etc.
- Design, synthesis and purification of protein bioconjugates, including monoclonal antibody and peptide bioconjugation, and dye conjugation.
- Characterization and evaluation of bioconjugates, including physiochemical properties, stability, conjugation efficiency, binding ability, etc.
- Perform data and statistical analyses using Excel and GraphPad Prism.
- Maintain accurate, detailed and timely records in electronic notebooks and generate internal technical reports as needed
- Summarize experimental results and present findings at internal meetings
- Ensure proper maintenance of laboratory equipment
- Excellent scientific presentation, communication, and interpersonal skills and can work effectively in a team environment.
Required/Preferred Experience:
- Bachelor degree plus minimum 6 years or Master degree plus minimum 4 years of experience or PhD plus 1 year of experience in Pharmaceutics, Chemistry, Biomedical Engineering, Chemical Engineering, or related field with a strong background in nanoparticle-based formulation development & analytical characterization.
- Hands-on experience in nucleic acid drug formulation and development (especially nanoparticle delivery technologies) is required.
- Experience in the following nanoparticle characterization / purification techniques: DLS, NTA, SDS-PAGE, UV, SEC, HPLC and fluorescence microscopy.
- Demonstrated ability to independently design, execute, interpret and present experimental results.
- Experience with bioconjugate and targeted delivery desirable
- Experience in data processing, analysis, statistics, and data interpretation is required
- Detailed-oriented, meticulous, have sense of urgency, high level of motivation, and research-orientated are required qualities
- High degree of organization and time management is required.
- Strong verbal and written communication skills, as well as a team spirit are required
- Demonstrates an insatiable curiosity, strong work ethic, has the eagerness to rise to challenges and ability to work equally well independently or in a team are key qualities
