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Scientist 1 Bioconjugation Chemistry
2 months ago
12 Month Contract (May extend or convert to permanent)
$70/hour W2
San Rafael, CA
Duties:
- Synthesis, optimization, and high-quality delivery of various polymer, protein/peptide, and lipidated bioconjugates in support of discovery and development of novel therapeutics, with an emphasis on oligonucleotides
- Development and implementation of new linker chemistries/spacers and bioconjugation methods for targeted drug delivery
- Leveraging appropriate purification and analytical characterization approaches for QC and validation
- Collaboration with internal and external partners for material transfer to support in vitro and in vivo POC experiments; assemble data packages and maintain quality control documentation through Benchling for final product delivery.
- Effectively partner with cross-functional teams, sharing insights, troubleshooting issues, and driving science forward from the bench
- Serve independently as bioconjugation technical lead and subject matter expert for internal and external project communications
- Perform data analysis, interpret, and present results during internal and external meetings; attend and participate in scientific proceedings.
- Prepare and optimize chemistry SOPs
- Participate and present data and share responsibility for project milestones
Requirements:
- Ph.D. in Chemical Engineering, Chemical Biology, Chemistry, or related fields is required; Scientist 1 will have 0-2 years of industry/post-doc experience relating to drug development
- Strong foundation in macromolecular chemistry, bioconjugation, analytical chemistry and/or chemical biology is strongly desired.
- A record of accomplishments/publications in relevant scientific discipline and some hands-on experience in oligonucleotide delivery is preferred but not required.
- Extensive experience with different bioconjugation strategies and optimizations thereof for polymers, proteins/peptides, lipids, oligonucleotides and other biomolecules
- In-depth experience in bioconjugate purification techniques including various liquid chromatography methods (e.g. RP, IEX, SEC, HIC, affinity, FPLC) and membrane filtrations (e.g. TFF)
- Prior experience in biochemistry techniques and analytical methods such as SEC-MALs, LCMS, SPR/BLI, ELISA, SDS-PAGE, enzyme activity assays, etc.
- Willingness to learn new bioconjugation chemistries or delivery modalities and work across diverse therapeutic areas to develop protein therapeutics.
- Strong analytical mindset and chemistry problem-solving with creative thinking
- The position requires organization skills, attention to detail, self-motivation, and strong teamwork in a fast-paced setting
