Senior Scientist I, QTAS and ADME Sciences

3 weeks ago


South San Francisco California, United States AbbVie Full time
Job Description


The QTAS (Quantitative, Translational and ADME Sciences) department at AbbVie Bay Area (ABA) in South San Francisco, CA is looking for a Senior Scientist I in the ligand binding assay (LBA) group.

Key responsibilities

  • Develop and validate biomarker LBA methods to support pre-clinical and clinical studies, including preanalytical sample processing, biomarker stability evaluation in the handling and storage conditions of such samples, and assay implementation.
  • Characterize internally developed and commercial biomarker analytical methods in a fit-for-purpose manner based on biomarker Context Of Use (COU). Follow and contribute to the generation of test methods, draft assay validation plans and validation reports.
  • Employ experience using and choosing LBA platforms and software for data acquisition, analyses, and presentations. Employ experience using automation systems for enhanced efficiency and data quality.
  • Perform manual and/or automated validation experiments and sample testing in compliance with Good Scientific Practices (GSPs) and Good Clinical Practices (GCP) guidelines. Review and perform data quality control to ensure integrity and compliance. Document and archive data to ensure traceability and quality.
  • Use computer skills and software to compile, analyze assay results, present at group meetings, and discuss with data statistician to facilitate data analysis.
  • Prepare buffers and reagents necessary for conducting assay runs. Conduct performance verifications on ligand binding assay lab instruments such as plate washers and readers.
Significant Work Activities -Continuous standing for prolonged periods (more than 2 consecutive hours in an 8 hour day)

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