Associate Director, Global Translational Bioinformatics Lead
2 weeks ago
Do you want to be part of an inclusive team that works to develop innovative therapies for patients? Every day, we are driven to develop and deliver innovative and effective new medicines to patients and physicians. If you want to be part of this exciting work, you belong at Astellas
Astellas Pharma Inc. is a pharmaceutical company conducting business in more than 70 countries around the world. We are committed to turning innovative science into medical solutions that bring value and hope to patients and their families. Keeping our focus on addressing unmet medical needs and conducting our business with ethics and integrity enables us to improve the health of people throughout the world. For more information on Astellas, please visit our website at .
This position is based in Northbrook, Illinois. Remote work from certain states may be permitted in accordance with Astellas' Responsible Flexibility Guidelines. Candidates interested in remote work are encouraged to apply.
Purpose and Scope:
Responsible for providing bioinformatics expertise to drug target selection, translational research, patient selection strategy and clinical biomarker analysis for multiple drug discovery and development programs. Develop bioinformatics analysis plans, perform hands-on analyses, and generate reports on internal and external data sets related to Astellas/partner discovery and development programs. Responsibilities also include developing new bioinformatics capabilities to support new modalities and therapeutic focus areas.
Essential Job Responsibilities:
- Leads bioinformatics strategy and develop analysis plans to address asset team's clinical development questions
- Utilizes state of the art bioinformatics methods, internal and external data to address translational questions related to indication selection, patient segmentation, and biomarker identification
- Conducts bioinformatics analysis of clinical trial omics data to support POM and patient selection
- Supports data ingestion and conducts analysis using translational and biomarker data management platforms
- Selects the appropriate data sets and analytical approaches for drug target identification and validation to support drug research
- Develops new analysis tools and databases to meet the current and future portfolio needs
- Identifies and evaluates external resources (CRO/academic collaborator) to complement internal capabilities
Required
- PhD. in computational biology, bioinformatics, or other biomedical sciences with a minimum of seven years' experience in applying bioinformatics approaches to drug discovery/development, preferably in a biopharma setting
- Strong publication record in peer reviewed journals
- Demonstrated experience in cancer genomics and omics data analyses, including experience with developing pipelines for next-generation sequencing data analysis and QC
- Strong capability in designing and performing bioinformatics analyses to address translational questions, and to obtain insight on patient segmentation and biomarker selection
- Excellent programming skills (including R, Python, SAS) and deep-knowledge for statistical analysis and machine learning
- Experience with data visualization using web application such as Shiny/plotly
- Experience with highly parallel, clustered, or supercomputing systems.
- Complete independence in providing project level bioinformatics support, from planning to execution and reporting.
- Strong communication skills and demonstrated ability to influence and lead in a matrix environment.
- Experience in analyzing single cell sequencing data and proteomics data
- Experience in maintaining in-house Laboratory Informatics Management System (LIMS)
- Administration experience of clustered-computing systems
- Experience with human genetics data and RWD
- Medical, Dental and Vision Insurance
- Generous Paid Time Off options, including Vacation, Sick time, plus national holidays including Heritage Days, and Summer and Winter Breaks
- 401(k) match and annual company contribution
- Company paid life insurance
- Annual Corporate Bonus and Quarterly Sales Incentive for eligible positions
- Long Term Incentive Plan for eligible positions
- Referral bonus program
Category Translational Medicine
Astellas is committed to equality of opportunity in all aspects of employment.
EOE including Disability/Protected Veterans
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