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Director, Precision Medicine and Companion Diagnostics
3 months ago
Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company's R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.
The Opportunity:
To aid in this mission, the Translational Medicine (TM) team at RevMed is seeking a highly motivated, scientifically creative, and collaborative Director to work in a fast-paced environment within a cross-functional team. This role will be the Translational Medicine lead for precision medicine and companion diagnostic (CDx) development for RAS(ON) inhibitors across different solid cancer types. Activities will be centered around analytical and clinical validation of CDx tests to support global regulatory submissions.
- Drive implementation of the CDx strategy to support early and late-stage development of portfolio assets.
- Lead or participate in joint project teams (JPTs) with diagnostic partners and internal cross-functional team members to ensure successful execution of analytical and clinical validation studies.
- Effectively collaborate with biomarker scientists, biomarker operations, clinical development, and clinical operations, to ensure successful collection and CDx testing of clinical trial samples.
- Collaborate closely with diagnostic partners and internal functions, including biostatistics, data management, medical writing, regulatory, and project management to enable regulatory submissions to support CDx approvals.
- In working with project management and finance, manage contracts, budgets, and timelines of key milestones associated with CDx development.
- Collaborate with clinical development and medical affairs to develop plans for publication of diagnostic test results in identifying biomarker-positive patient populations.
- Collaborate with commercial colleagues to develop patient identification strategies (e.g. access to diagnostic tests) for launch readiness.
- A Ph.D. in cancer biology, cell/molecular biology, genomics or equivalent with 6+ years of industry experience.
- 3+ years of experience in CDx development is required.
- Broad knowledge and understanding of established and novel technologies employed in clinical diagnostic assays (e.g. NGS, IHC, PCR) are required.
- Excellent scientific and business communication skills, strong interpersonal/collaboration skills and planning skills.
- Ability to think critically and creatively and be able to work independently to determine appropriate resources for resolution of problems.
- Ability to multi-task and thrive in a fast-paced innovative environment.
- A great teammate, who listens effectively and invites response and discussion.
- Commitment to Revolution Medicines' Core Values: Tireless Commitment to Patients, Transformative Science, Exceptional Together, Total Integrity, Inclusiveness and Fairness.
- Experience in oncology drug development in the biopharmaceutical industry is preferred.
Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.
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