Research Associate, Proteomics

2 weeks ago

Cambridge, Massachusetts, United States Flagship Ventures Full time

FL94 is a NewCo pioneering the discovery of protein editors as a new category of medicines. To reach this goal we are creating the industry's first generative covalent chemistry platform foundationed on merging AI with a massively scalable proprietary data generation paradigm that will programmably create actionable covalent small molecules targeted to any protein class. Both small molecule modulation of canonical function (using mono-valent editors) and novel induced proximity-driven functions (using bi-valent editors) are in scope to treat diseases spread within the full human proteome, not just the currently ligandable.

Position Summary:

FL94 is seeking a motivated Research Associate to join the proteomics team. In this role you will be a critical member of a team responsible for establishing and integrating state of the art chemical proteomics technologies and workflows across all functions within the protein editing platform. Successful candidates will be able to thrive in a lab-based role, as a motivated member of a face-paced team. The individual will have demonstrated evidence of rapidly understanding and achieving expertise in new technologies, while supporting multiple functions. They will be interested in contributing at the bench and be dedicated to scientific development of themselves and their team.

Key Responsibilities:

  • Maintain and develop automation capabilities using existing hardware platforms (e.g. Bravo liquid handling) for cell prep and MS analysis
  • Ensure rapid and accurate turnaround of data to drive achievement of key project goals
  • Work with biology, chemistry and compound management teams to troubleshoot and optimize screening high value targets
The successful candidate will have all the following skills necessary to perform in a fast-paced, purposeful, highly integrated, and pioneering environment
  • B.S. or M.S. in analytical chemistry, chemical biology, biochemistry or other related fields with 0-3 years of experience in an industry setting
  • Proven hands-on experience in 96-well plate-based cell and biochemical assays
  • Experience with mammalian cell culture
  • Experience with various affinity-based enrichment assays (e.g. immunoprecipitations) and their subsequent analysis
  • Experience operating, optimizing and troubleshooting automated liquid handlers is preferred
  • Strong understanding of relevant concepts in cancer biology, protein biochemistry, and a general understanding of chemical reactivity is preferred
  • An understanding of LC-MS methods, principles and sample preparation is a plus
  • A highly engaged, collaborative and goal/results-orientated style, capable of interfacing and delivering results for multiple functional leads
  • Outstanding decision making, organizational and analytical skills
Location: Cambridge, MA

About Flagship

Flagship Pioneering is a biotechnology company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the companies Flagship has founded have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Recruitment & Staffing Agencies*: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect there to.*

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