Scientist, mAb Prep Lab/Downstream Process Development

3 weeks ago

Kalamazoo, United States Zoetis Full time
Role Description

The candidate will work in the Protein Preparation Laboratory and Downstream Process Development group within Biologics Process Development of Zoetis Development Sciences and Technologies.

The successful applicant will work with other team members to produce multiple preparations of monoclonal antibodies and therapeutic proteins in a fast-paced R&D space engaged in numerous projects. The incumbent is expected to work hands-on at the bench while learning strong technical skills in both upstream production and downstream purification workflows.

They are expected to work in partnership with colleagues in upstream/downstream development, formulation development, and bioanalytical science. In addition, the candidate will be expected to maintain Good Documentation Practices in support of global regulatory submissions for product licensure. Moreover, they will be involved in identification and development of new technologies and will provide support to Downstream and Upstream development. They will also assist with new product transfers to Biological Manufacturing sites within Zoetis.

Additional duties and responsibilities include:
  • Aseptically culture cells and production systems such as CHO cells for the expression of monoclonal antibodies (mAb) and recombinant proteins.
  • Operate bench- and mid-scale bioreactor systems that are used within the laboratory to routinely produce mAbs and therapeutic proteins.
  • Operate multiple modalities of chromatography and filtration systems that are routinely used to isolate, purify, and concentrate mAbs and proteins.
  • Coordinate with cell culture and downstream development groups on the procedures, raw materials and equipment required for a successful mid-scale batch.
  • Learn to serve as a company resource in protein isolation, purification, and scaling of bioreactor systems and downstream processes as it relates to manufacturing processes.
  • Serve as a technical liaison between Biologics Process Development - Downstream Development group, Upstream Development team, and other partner groups such as Discovery, Pilot, GMS and Regulatory.
  • Establish a network within Zoetis and with key suppliers and institutions to serve business needs, and provide cost effective, innovative solutions for Zoetis.
  • Regularly communicate via excellent written and verbal interactions, as well as clear technical presentations to project teams and management.
  • Work within GLP/cGMP documentation standards to provide high quality, regulatory compliant technical documentation in support of technology transfer within the company or to contract manufacturers and well as to support regulatory filings for new product registrations.
  • Strive for continuous improvement in the existing workflow, technologies, and techniques utilized in bioprocess development.
  • Maintain electronic laboratory notebooks and records in accord with scientific protocol and applicable Standard Operating Procedures.
  • Demonstrate excellent organizational skills in order to engage in multiple projects.
  • Bolster the highly collaborative team environment necessary across the biopharmaceutical development programs.

The position is based in Kalamazoo (Michigan, USA) with interactions with colleagues and external partners located around the globe.

Qualifications:

Educational Background:
  • Minimum: B.S. Biochemistry, Biotechnology, Chemical/Biochemical Engineering, or a related field
  • Preferred: BS with 3-8 years of experience or MS with 0-6 years of experience

Work Experience/Skills:

Minimum:
  • Familiarity/Experience in multiple types of low pressure chromatography development.
  • Familiarity/Experience in crossflow and dead-end filtration development.
  • Familiarity/Experience in the purification of monoclonal and hybridoma antibodies.
  • Familiarity/Experience with basic analytical methods which may include HPLC, gel electrophoresis, and total protein analysis.
  • Familiarity/Experience in aseptic technique and cell culture.
  • Familiarity/Experience in bioreactor/fermenter operation.
  • Strong communication skills, both oral and written. Strong interpersonal skills, ability to work effectively with all types of personalities.

Desirable:
  • Experience with mid-scale and/or large scale protein/vaccine preparations.
  • Experience with Design of Experiments (DOE) planning, execution, and analyzing data.
  • Experience with automated chromatography systems such as AKTA.
  • Experience with principles of scale-up and scale-down to bioreactor systems and downstream processes.
  • Knowledge of regulatory issues associated with USDA and EU biologics submissions.
  • Knowledge of GXPs, including Process validation.

Other Attributes Desirable:
  • Highly computer literate. Capable of quickly learning and adapting to new computer programs.
  • Experience with technical transfers.
  • Ability to multi-task; working on multiple projects simultaneously.
  • Team player, positive attitude, good organizational skills, and highly motivated.

Full time

Regular

Colleague

Any unsolicited resumes sent to Zoetis from a third party, such as an Agency recruiter, including unsolicited resumes sent to a Zoetis mailing address, fax machine or email address, directly to Zoetis employees, or to Zoetis resume database will be considered Zoetis property. Zoetis will NOT pay a fee for any placement resulting from the receipt of an unsolicited resume.

Zoetis will consider any candidate for whom an Agency has submitted an unsolicited resume to have been referred by the Agency free of any charges or fees. This includes any Agency that is an approved/engaged vendor but does not have the appropriate approvals to be engaged on a search.

Zoetis is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status or any other protected classification. Disabled individuals are given an equal opportunity to use our online application system. We offer reasonable accommodations as an alternative if requested by an individual with a disability. Please contact Zoetis Colleague Services at zoetiscolleagueservices@zoetis.com to request an accommodation. Zoetis also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must possess or obtain authorization to work in the US for Zoetis. Zoetis retains sole and exclusive discretion to pursue sponsorship for the acquisition or maintenance of nonimmigrant status and employment eligibility, considering factors such as availability of qualified US workers. Individuals requiring sponsorship must disclose this fact. Please note that Zoetis seeks information related to job applications from candidates for jobs in the U.S. solely via the following: (1) our company website at www.Zoetis.com/careers site, or (2) via email to/from addresses using only the Zoetis domain of "@zoetis.com". In addition, Zoetis does not use Google Hangout for any recruitment related activities. Any solicitation or request for information related to job applications with Zoetis via any other means and/or utilizing email addresses with any other domain should be disregarded. In addition, Zoetis will never ask candidates to make any type of personal financial investment related to gaining employment with Zoetis.PandoLogic. Category: , Keywords: Pharmacology Scientist

  • Applications Development Scientist

    2 weeks ago

    Kalamazoo, United States Lincoln Search Consultants Inc Full time

    Are you passionate about science and innovation? Do you enjoy solving complex problems and supporting breakthrough products? Our client is looking for an Applications Development Scientist to join their team. In this role, you'll be at the intersection of science and business, helping to drive their success by supporting the sales team with your expertise. ...

  • Laboratory Automation and Programming Specialist

    6 days ago

    Kalamazoo, United States Eurofins USA PSS Insourcing Solutions Full time

    Job DescriptionJob DescriptionCompany DescriptionAre you looking for an exciting opportunity, a rewarding, enriching, and fulfilling career, and the opportunity to grow to greater levels of success with a company that values you? Then look no further! Join Eurofins PSS: a world class company that is growing by leaps and bounds while making a difference to...

  • Biological Development Scientist

    2 days ago

    Kalamazoo, United States Eurofins USA PSS Insourcing Solutions Full time

    Job DescriptionJob DescriptionCompany DescriptionAre you looking for an exciting opportunity, a rewarding, enriching, and fulfilling career, and the opportunity to grow to greater levels of success with a company that values you? Then look no further! Join Eurofins PSS: a world class company that is growing by leaps and bounds while making a difference to...

  • Veterinary Research Scientist

    4 days ago

    Kalamazoo, Michigan, United States Zoetis Full time

    Job SummaryZoetis is seeking an experienced and highly motivated veterinarian to join our team as a Senior Scientist/Principal Scientist - Clinical Veterinarian. This role will provide clinical veterinary support to research animals at our Richland and Kalamazoo sites, working closely with research scientists and study personnel to deliver exceptional animal...

  • Senior Research Scientist

    16 hours ago

    Kalamazoo, Michigan, United States Medix™ Full time

    Job SummaryThe Senior Research Scientist will serve as the single point of study control and overall planning and conduct of the study in accordance with applicable regulatory guidelines and contemporary scientific practice. Additionally, the Senior Research Scientist will ensure that all Good Laboratory Practices (GLP) are met, and that the outcome of the...

  • Lead Data Scientist

    2 months ago

    Kalamazoo, United States Level Data LLC Full time

    Job DescriptionJob DescriptionAbout UsLevel Data is a fast-growing, software-as-a-service company. We are on a mission to change lives in the education technology space. We are a passionate group of people who always put our customers first. Our core values are at the heart of all we do. We Listen First and always assume positive intent. We will continually...

  • Research Scientist

    2 weeks ago

    Kalamazoo, United States Medix™ Full time

    Role SummaryThe Research Scientist (RS) will be engaged in serving as the single point of study control and overall planning and conduct of the study in accordance with applicable regulatory guidelines and contemporary scientific practice. Additionally, the RS will ensure that all Good Laboratory Practices (GLP) are met, and that the outcome of the study is...

  • Senior Research Scientist

    1 week ago

    Kalamazoo, Michigan, United States Piper Companies Full time

    About Piper Health & SciencesPiper Health & Sciences is a leading life sciences organization dedicated to advancing the field of cell and gene therapy. We are seeking a highly skilled Research Scientist to join our team and contribute to the development of innovative treatments.Job SummaryThe Research Scientist will serve as Principal Investigator and/or...

  • Data Scientist Sr

    3 months ago

    Kalamazoo, United States The PNC Financial Services Group, Inc Full time

    Position Overview At PNC, our people are our greatest differentiator and competitive advantage in the markets we serve. We are all united in delivering the best experience for our customers. We work together each day to foster an inclusive workplace culture where all our employees feel respected, valued, and have an opportunity to contribute to the company's...

  • Laboratory Automation Specialist

    3 weeks ago

    Kalamazoo, United States Zoetis Full time

    Senior Scientist, Lab Automation Specialist Zoetis is a global animal health company dedicated to nurturing our world and humankind by advancing care for animals. We strive to create an atmosphere where colleagues feel valued and supported, can give their best every day, and are proud of the company where they work. Building on 70+ years of experience, our...

  • Analytical Chemist

    1 month ago

    Kalamazoo, United States Eurofins USA PSS Insourcing Solutions Full time

    Job DescriptionJob DescriptionCompany DescriptionEurofins Scientific is an international life sciences company, providing a unique range of analytical testing services to clients across multiple industries, to make life and our environment safer, healthier and more sustainable. From the food you eat, to the water you drink, to the medicines you rely on,...

  • Cell & Molecular Scientist

    3 weeks ago

    Kalamazoo, United States Genemarkers Full time

    Position Description: The Cell & Molecular Laboratory Technician is responsible for working independently to perform experiments that fulfill the Company’s needs for both the R&D Testing and CLIA/CAP Clinical PGx Testing divisions. Responsibilities may include project management, communicating with study sponsors and troubleshooting technical issues to...

  • Cell & Molecular Scientist

    3 months ago

    Kalamazoo, United States Genemarkers Full time

    Position Description: The Cell & Molecular Laboratory Technician is responsible for working independently to perform experiments that fulfill the Company’s needs for both the R&D Testing and CLIA/CAP Clinical PGx Testing divisions. Responsibilities may include project management, communicating with study sponsors and troubleshooting technical issues to...

  • Food Service Worker

    4 days ago

    Kalamazoo, Michigan, United States Compass Group Careers Full time

    Job SummaryJob Title: Food Service Worker - Prep and ServeJob Summary: We are seeking a skilled Food Service Worker to join our team at Chartwells K12. As a Food Service Worker, you will be responsible for preparing, presenting, and serving food to our customers in a fast-paced and dynamic environment.Key Responsibilities:Food Preparation: Prepare...

  • Prep Cook

    4 months ago

    Kalamazoo, United States Crow's Nest Full time

    Description Responsible for preparing the kitchen to be ready for service the following day. This would include both food preparation and cleaning. Experience is helpful but on-the-job training is provided for applicants who are new to the restaurant industry. Quick two step interview process lets you and us know how things will go on day one. Great way to...

  • RN Registered Nurse

    3 days ago

    Kalamazoo, Michigan, United States Ascension Full time

    Job SummaryWe are seeking a highly skilled Registered Nurse to join our Cardiac Cath Lab team at Ascension Borgess Hospital. As a Cardiac Cath Lab Registered Nurse, you will be responsible for providing high-quality patient care in a fast-paced environment.Key ResponsibilitiesProvide professional nursing care to patients undergoing cardiac catheterization...

  • Head of Quality Control

    4 weeks ago

    Kalamazoo, United States Zoetis Full time

    POSITION SUMMARYThe Head of Quality Control (QC) is responsible for managing an organization performing chemical and microbiological release testing on Raw and API materials used in the manufacture of Drug Products, as well as release and stability testing on Finished Drug Products.POSITION RESPONSIBILITIESThe Head of QC will report to the Site Quality Lead...

  • Operational Process Specialist

    2 weeks ago

    Kalamazoo, Michigan, United States Actalent Full time

    Job Title: Operational Process SpecialistJob OverviewAn Operational Process Specialist is sought to oversee setups, methodologies, and workflows across various operational sites. This position entails spearheading process control documentation initiatives, managing extensive projects, and enhancing the efficiency of internal systems. The Operational Process...

  • Manufacturing Process Specialist

    2 weeks ago

    Kalamazoo, Michigan, United States Pactiv Evergreen Full time

    Overview:Pactiv Evergreen Inc.(NASDAQ:PTVE)is a prominent producer and distributor of fresh foodservice and food merchandising products, as well as fresh beverage cartons across North America and select international markets. The company caters to a diverse clientele, including full-service and quick-service restaurants, foodservice distributors,...

  • Manufacturing Process Specialist

    2 weeks ago

    Kalamazoo, Michigan, United States Actalent Full time

    Job Title: Manufacturing Process Specialist Job Description A Manufacturing Process Specialist is required to oversee setups, procedures, and workflows across various operational sites. This position entails leading documentation efforts for process controls, managing extensive projects, and enhancing the efficiency of internal systems. The Manufacturing...