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Associate Scientist
4 months ago
Sigma Systems is seeking an Associate Scientist
Onsite 5 days, New Haven only, Parking will be reimbursed
Responsibilities:
The position is required to join Injectable Drug Product Development group of Client's Analytical and Pharmaceutical Development department.
This position is required to conduct studies to enable Drug Product characterization activities, including combination products at high protein concentration, as well as commercial products.
The job entails experimental work on various aspects of Drug Product characterization, including formulation development, safety risk assessment of excipients as well as process reagents, extractables and leachables, in use compatibility studies for intravenous and subcutaneous administration, process development to support drug product manufacturing support, particulates testing.
The ability to work with minimal supervision as well as part of the team is essential.
The position entails execution of the studies and data processing and compiling to generate and support development reports as well as other required documentation.
Understanding of assay development, biotherapeutics development is a plus. Understanding of the basic principles of protein chemistry and/or drug product process is required.
Experience with electronic record keeping software, like ELN, EndNote, e–logbooks; maintenance of laboratory instrumentation (organizing PMs, data backup, SW upgrade, etc.) and familiarity with design and maintenance of databases will be a plus.
Execute development studies for Alexion pharmaceuticals' drug candidates and commercial products, support tech transfer activities for internal manufacturing and contract manufacturing sites
Assist in preparation of internal technical reports on the executed studies with minimal supervision for the Alexion product candidates
Participate in Department meetings and other technical and team building activities
Requirements:
BS in Chemistry, Biochemistry, Biophysics, Chemical engineering, or relevant field with 2+ years of experience or MS degree with 1+ years of relevant experience is required. Solid background in protein chemistry, chemistry, biochemistry, or equivalent is highly preferred.
Position requires scientific and practical knowledge of protein chemistry or drug product process
Previous experience in biotherapeutics development as well as understanding of the biotechnology products life cycle and factors impacting protein molecule stability is a plus
Hands–on experience with instrumentation, used in protein pharmaceutical and analytical development as well as characterization and knowledge of cGMP and quality guidelines is a plus
Ability to take initiative in problem solving and finding solutions to scientific challenges with minimal supervision is preferred
Shows ability to take instructions and execute experiments and other activities with minimal supervision is required
The individual must be able to work in a collaborative setting and has ability to adhere to timelines with minimal supervision is essential
Excellent interpersonal skills are required, as is the strong ability to communicate effectively
