Senior Research Associate I, Biology

1 month ago

South San Francisco, United States Maze Therapeutics Full time

The Position: 

Imagine yourself as a key player in a cutting-edge team that’s transforming the way we approach disease treatment.  As a Senior Research Associate I (contract) in the Biology group, you will leverage your expertise in tissue culture and your foundation in molecular biology to advance complex cell models for drug discovery across multiple therapeutic areas.  You will contribute to new target identification and the design and validation of novel disease-modifying therapeutics.  Step into a role where your expertise and ideas are valued and become part of a mission that’s changing the future of medicine. 

Your Impact: 

Establish, scale, and perform tissue culture procedures to support the differentiation of induced pluripotent stem cells (iPSCs) into various lineages, such as renal and cardiometabolic, using both 2D and 3D organoid cultures. Utilize a range of molecular and cellular biology assays to analyze cell cultures. Techniques include qPCR, Western blots, high content imaging, flow cytometry, and RNA-seq. Support internal cell-based screens and generate CRISPR engineered iPSCs to drive discovery and innovation. Work closely with other scientists, bioinformaticians, and computational biologists to support assay development, experimental design, troubleshooting, sample analysis, data interpretation, and report generation. 

Skills and Qualifications: 

Bachelor’s degree with 4+ years of experience or a Master’s degree with 1+ years’ experience in life sciences  Strong tissue culture skills, preferably with iPSCs, and a thorough understanding of biological procedures are essential.   Experience developing and optimizing cell-based and biochemical assays using a range of readout technologies, such as imaging, FACS, ELISA, qPCR, etc. Excellent communication, collaboration, time-management, and organizational skills   Excited by challenges and capable of working independently while thriving in a team environment. 

 

About Maze Therapeutics

Maze Therapeutics is a biopharmaceutical company that is harnessing the power of human genetics to transform the lives of patients, with a focus on genetically informed therapies for common diseases, such as chronic kidney disease, . and seeks to focus expertise and resources towards underserved communities. Maze applies variant functionalization in tandem with advanced data science methods and a robust suite of research and development capabilities to advance a pipeline of novel precision medicines. Maze has developed the Maze Compass Platform™, a proprietary, purpose-built platform to understand and integrate the critical step of variant functionalization into each stage of drug development. Utilizing the Maze Compass Platform™, Maze is building a broad portfolio of wholly owned and partnered programs. Its two lead programs are focused in Chronic Kidney Disease (CKD), a condition that impacts an estimated 37m individuals. The first program in CKD addresses a genetic subset of the common disease that has a disproportionate impact on the Black Community. Maze is based in South San Francisco.

Our People

Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients. 

Our Core Values

Further Together – Our path is paved with challenges, but with resilience and a team-first mentality, we’ll achieve our mission.  

Impact Obsessed – We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others. 

Stand True – Our integrity is foundational; it guides us no matter the obstacle. 

 

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