Current jobs related to Principal Scientist - Bothell - Pfizer
-
Principal Scientist
1 week ago
Bothell, Washington, United States Pfizer, S.A. de C.V Full timeJob Title: Principal ScientistWe're committed to delivering breakthroughs that change patients' lives. Our Research and Development team is at the forefront of this mission, working to translate advanced science and technologies into innovative therapies and vaccines.Job SummaryWe're seeking a highly skilled Principal Scientist to join our Oncology Research...
-
Principal Scientist
3 weeks ago
Bothell, United States Pfizer, S.A. de C.V Full timeWe're in relentless pursuit of breakthroughs that change patients' lives. We innovate every day to make the world a healthier place.To fully realize Pfizer's purpose – Breakthroughs that change patients' lives – we have established a clear set of expectations regarding "what" we need to achieve for patients and "how" we will go about achieving those...
-
Lead Scientist, Chemical Engineering
4 weeks ago
Bothell, Washington, United States Immunome Full timeJob Title: Lead Scientist, Chemical EngineeringCompany: Immunome, Inc.Company Overview:Immunome is a pioneering biotechnology firm focused on the creation of innovative and effective targeted cancer treatments. Our diverse portfolio aims to tackle each target with the most suitable modality, including small molecules, antibody-drug conjugates (ADCs), and...
-
Principal Scientist
1 month ago
Bothell, United States Pfizer Full timeWhy Patients Need YouPfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or...
-
Bothell, United States Pfizer Full timeROLE SUMMARYThe ADC (Antibody Drug Conjugate) Chemistry group is seeking a highly motivated, creative, and experienced computational chemist with a proven track record of success in drug discovery, to develop novel payloads and linkers for antibody-drug conjugates (ADCs).You will apply your background in drug development, medicinal chemistry, and...
-
Principal Scientist, Therapeutic Assays
3 weeks ago
Bothell, Washington, United States Lundbeck Full timeAre you interested in becoming part of a team where the mission is impactful, the challenges are intricate, and you can witness the outcomes of your efforts? Lundbeck Seattle BioPharmaceuticals (Lu-SBP) is at the forefront of Process Development for Biologics within the global Lundbeck CMC organization. Since joining Lundbeck, Lu-SBP has played a crucial...
-
Principal Scientist, Cell
2 weeks ago
Bothell, United States Pfizer Full timeWhy Patients Need You This position will provide the opportunity to make a positive impact during early stages of cancer drug development by optimizing the process of evaluating drug candidates and de-risking potential toxicities. These efforts will ultimately contribute to the larger goal of making therapeutics safer and more effective for cancer...
-
Bothell, Washington, United States Pfizer Full timeJob SummaryThe ADC Chemistry group at Pfizer is seeking a highly motivated and experienced computational chemist to develop novel payloads and linkers for antibody-drug conjugates (ADCs). As a key member of our team, you will apply your background in drug development, medicinal chemistry, and computational chemistry to develop new anticancer therapies.Key...
-
Bothell, Washington, United States Pfizer Full timeJob SummaryWe are seeking a highly motivated and experienced computational chemist to join our ADC Chemistry group. As a key member of our team, you will apply your expertise in computational chemistry to develop novel payloads and linkers for antibody-drug conjugates (ADCs). Your background in structure-based drug discovery and computational chemistry will...
-
Principal Scientist, Cell
2 weeks ago
Bothell, United States Pfizer Full timeWhy Patients Need YouThis position will provide the opportunity to make a positive impact during early stages of cancer drug development by optimizing the process of evaluating drug candidates and de-risking potential toxicities. These efforts will ultimately contribute to the larger goal of making therapeutics safer and more effective for cancer...
-
Senior Associate Scientist, Protein Solutions
1 month ago
Bothell, United States Pfizer Full timeWhy Patients Need YouPfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or...
-
Senior Associate Scientist, Protein Solutions
1 month ago
Bothell, United States Pfizer Full timeWhy Patients Need YouPfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or...
Principal Scientist
3 months ago
ROLE SUMMARY
The successful candidate will join the Translational Modeling and Simulation (TMS) team within Pfizer's Department of Pharmacokinetics, Dynamics, and Metabolism (PDM). As a core member of multidisciplinary project teams, the candidate will leverage principles and practices of quantitative translational pharmacology (PKPD, PBPK, QSP) to influence decision making from project ideation through early clinical development for both biologic and small molecule modalities. Emphasis will be in oncology with a particular focus on antibody-drug conjugates (ADCs), but also with opportunities in other therapeutic areas such as immunology and inflammation, metabolic diseases, and infectious diseases.
Responsibilities:
Work closely with multidisciplinary project teams to develop and implement mechanistic mathematical models of pharmacology to aid in target selection, target prioritization, therapeutic modality selection, chemical/biotherapeutic optimization, quantification of exposure-response relationships, biomarker characterization and early clinical trial design
Collaborate with research biology in the development of in-vitro assays and in-vivo models to generate data that inform preclinical-to-clinical translational PKPD models
Provide expert support to project teams to design, execute and interpret quantitative pharmacology studies
Partner with colleagues in Clinical Pharmacology and Pharmacometrics to develop end-to-end alignment in model-informed drug development (MIDD) plans and to collectively advance the science and impact of mechanistic modeling and simulation.
Network as appropriate with global experts in the department and other groups to share learnings and enhance consistency in best practices across sites, disease areas, and interventional modalities
Keep up to date with emerging literature in the area of mechanistic modeling and simulation sciences
Continue to build a personal track record of publication in the area of PKPD modeling and simulation and contribute to PDM's external publication/presentation goals consistent with our sustained investments in the area of modeling and simulation
Some travel required.
Basic Qualifications:
Ph.D. degree or equivalent experience in pharmaceutical sciences, systems pharmacology, pharmacometrics, engineering, mathematics, physics or similar disciplines where modeling and simulation is emphasized.
2+ years of pharmaceutical industry or related experience in developing and applying quantitative pharmacology models (e.g. PBPK, PKPD, QSP) models to guide project teams from early discovery to early clinical development
Excellent understanding of theory, principles and statistical aspects of advanced mathematical modeling and simulation
Ability to effectively translate/condense/summarize outcomes of modeling and simulation analyses into useable information for multidisciplinary project teams
Good team player and communicator
Ability to work with on-site and remote colleagues
Good listener and ability to effectively interact with colleagues with a variety of backgrounds
Keen to interact as a modeling and simulation expert with matrix project teams working closely with within PDM as well as biology, protein engineering, chemistry, safety and clinical scientists
Strong belief that modeling and simulation can have a significant positive impact on research projects
In depth, hands-on knowledge of the state-of-the-art modeling and simulation software with (NONMEM, MATLAB, Monolix, Berkeley-Madonna, R or comparable applications)
Ability to learn new areas of biological sciences and build on a solid foundation of quantitative skills to develop mechanistically relevant PKPD models
Ability to keep up to date with and propose the implementation of scientific and technological developments in the area of PKPD modeling and simulation
Motivated to develop a career as a hands-on, technical modeling and simulation expert in a preclinical drug discovery environment
Committed to sharing technical expertise and the development of self and others
Preferred Qualifications:
Experience in working in the oncology disease area with a focus on ADCs
Familiarity with novel biotherapeutic modalities (bispecifics, Fc-fusions and other targeting agents)
Familiarity with dispositional and pharmacological aspects of both small molecules and biologics.
PHYSICAL/MENTAL REQUIREMENTS
- Ability to perform mathematical and logic tasks
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
- Some travel is required
Work Location Assignment:On Premise
Relocation support available
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Research and Development
