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Sr. Scientist I, Analytical Development
2 months ago
Department
64 - QC & Analytical Development
Employment Type
Full Time
Location
Redwood City, CA
Workplace type
Onsite
DescriptionCodexis, a biotechnology company based in Redwood City, CA, is looking to hire a Sr. Scientist I, Analytical Development.
Codexis is a leading enzyme engineering company leveraging its proprietary CodeEvolver® technology platform to discover, develop and enhance novel, high-performance enzymes and other classes of proteins. Codexis enzymes solve for real-world challenges associated with small molecule pharmaceuticals manufacturing and nucleic acid synthesis. The Company is currently developing its proprietary ECO Synthesis™ platform to enable the scaled manufacture of RNAi therapeutics through an enzymatic route. Codexis enzymes can drive improvements, such as higher yields, reduced energy usage and waste generation, improve efficiency in manufacturing and greater sensitivity in genomic and diagnostic applications.
To meet the goals we’ve set for ourselves, we look for individuals who are driven, eager to grow and ready to embrace meaningful challenges. We empower employees to be authentic, ambitious, agile and have the courage to take action where they can make a positive impact.
Come join us on this journey to transform the enzyme engineering landscape for the betterment of human health.
About the Opportunity: The is responsible for leading analytical method development and validation to support Codexis product development and release. This role offers the opportunity to provide technical mentorship to junior colleagues and contribute analytical insights in cross functional teams to support process development and quality control for our established biocatalyst and emerging RNA therapeutics businesses.
This role will be based onsite in Redwood City, CA. If any of the below describes you, we would love to meet you
In this role you will be responsible for: Independently lead the development and validation for analytical methods for activity, purity, content and other quality attributes of pharma enzymes, life sciences enzymes, RNA-based therapeutics and other Codexis products. Develop reliable analytical test methods following rigorous scientific methodology and industry standard application of ICH guidelines. Independently design and conduct physicochemical characterization, forced degradation and analytical studies on Codexis' products to support process development. Perform data processing, evaluation and interpretation of test and experimental data, drawing conclusions based on the results. Prepare test methods, protocols, summary reports and technical documentation. Perform method transfer, qualification and validation in accordance with FDA and ICH guidelines. Act as the Analytical Development SME for project teams by communicating method status, analytical data and resolution of project technical issues. Provide technical oversight of trouble shooting and analytical investigations in cross-functional teams. Mentor and guide junior level scientists and associates.
The essential requirements of the job include: PhD in Analytical Chemistry, Chemistry, Biochemistry, or related discipline with 5+ years’ relevant industry experience; or MS or BS with 9-12 years’ relevant experience. At least three years of cGMP experience in a regulated lab. Broad hands-on experience with analytical techniques and instrumentations and proven track record in analytical method development and validation, e.g., enzyme kinetics, colorimetric and fluorescent plate-based assays, ELISA, qPCR, UV-Vis, RP-HPLC, IEX-HPLC, SEC, CE, SDS-PAGE, etc. Strong attention to detail and excellent record documentation skills. Sound understanding of ICH Quality Guidelines related to analytical method development/validation, impurities and stability.
Additional experience that would be valuable for this role includes: Experience working with enzymes and oligonucleotides/nucleic acids. Strong theoretical understanding and extensive hands-on experience with LCMS.
CODEXIS PAY TRANSPARENCY: The anticipated salary range for candidates who will work in Redwood City is $138,500 to $162,000. The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience within the job, type and length of experience within the industry, education, etc. Codexis is a multi-state employer, and this salary range may not reflect positions that work in other states.
What can Codexis offer you?Medical, Dental and Vision Insurance Basic Life, AD&D, Short- and Long-Term Disability Insurance 401k with Company Match up to 4% Company Equity Generous Paid Time Off including 18 Company Holidays (with a summer and winter shutdown), Vacation, and Wellness Time Annual Lifestyle Account for reimbursement of fitness programs, equipment and more Employee Stock Purchase Program (ESPP) Flexible Spending Accounts (Commuter/Parking, Dependent Care & Healthcare) Student Debt Program (Company Contribution to Loans) Mental Health Wellness Program Subsidized onsite lunch program Onsite Gym Facilities Paid Parental Leave And More
About Codexis Inc
Why join Codexis?
At Codexis we offer a very competitive compensation package and beyond excellent benefits We foster career growth, continued education and upskilling through our mentorship program and learning and development opportunities. You will learn and work alongside inspirational leaders and colleagues who are equally passionate about our mission and committed to fostering an inclusive, growth-centered, and rewarding culture. Diversity is valued and mutual trust is of paramount importance to the ethos at Codexis. The people, the culture and working with others with a common goal is what makes Codexis a great place to work.
For more information, visit www.codexis.com.
NO AGENCIES OR THIRD PARTIES
Codexis is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status.
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