Vice President, Neuroscience Pharmacology and Translational Biomarkers
1 week ago
Arvinas is a clinical-stage biotechnology company dedicated to improving the lives of patients suffering from debilitating and life-threatening diseases through the discovery, development, and commercialization of therapies that degrade disease-causing proteins. Arvinas uses its proprietary PROTAC® Discovery Engine platform to engineer proteolysis targeting chimeras, or PROTAC® targeted protein degraders, that are designed to harness the body’s own natural protein disposal system to selectively and efficiently degrade and remove disease-causing proteins.
The company is progressing multiple investigational drugs through clinical development programs, including vepdegestrant, targeting the estrogen receptor for patients with locally advanced or metastatic ER+/HER2- breast cancer; ARV-102, targeting LRRK2 for neurodegenerative disorders; and ARV-393, targeting BCL6 for relapsed/refractory non-Hodgkin Lymphoma.
In April 2024, Arvinas entered into a transaction with Novartis, including a global license agreement for the development and commercialization of the clinical stage PROTAC® androgen receptor protein degrader ARV-766 for the treatment of prostate cancer. The transaction closed in May 2024.
#TeamArvinas is made up of approximately 450 passionate and curious employees, whose diverse thoughts and perspectives are highly valued. Arvinas employees embrace the freedom to pursue innovation, think creatively, and give back. They are driven by the company’s values and mission – to improve the lives of patients with serious diseases by pioneering therapies created with our revolutionary PROTAC® protein degradation platform. We’re really excited about the work we’re doing inside and outside of Arvinas, and think you will be, too. But don’t just take our word for it – learn more about life at Arvinas and what employees have to say.
Position Summary
The Vice President of Neuroscience Pharmacology and Translational Biomarkers is responsible for enterprise leadership of all aspects of driving the neuroscience portfolio. This includes managing exploratory new target selection, generation of in vitro and in vivo data used to develop pharmacokinetic / pharmacodynamic relationships, and the identification of translational biomarkers to support lead optimization and clinical development of PROTAC degrader molecules for severe neurologic disorders.
This position reports to SVP of Neuroscience and Platform Biology and will be located at our headquarters in New Haven, CT.
Principal Responsibilities
Key responsibilities of this role include, but are not limited to:
Defines, revises and champions asset discovery and development strategies while implementing plans to support prioritization and expeditious progression of the neuroscience portfolio. Builds, leads and inspires a high-performing team through mentorship and development of leadership, scientific and technical capabilities. Enables team to make critical choices in identifying and developing appropriate preclinical in vivo models to support lead identification and optimization based on a deep understanding of disease and target biology, downstream pathways, and target-dependent functional endpoints. Guides team of scientists to build high-quality reliable ex vivo target engagement assays, pathway biology assays, and disease biomarker assays to support preclinical pharmacology studies. Contributes to the design and data analysis strategy of preclinical pharmacology studies to characterize compound activity and establish pharmacokinetic and pharmacodynamic relationships to drive compound optimization and inform human dose projections. Owns and develops the early clinical biomarker strategy across the neuroscience portfolio. Manages the team to develop and execute high quality robust qualified assays to quantify translational biomarkers for targets for tauopathies, Parkinson’s Disease, Huntington’s disease, and other neurodegenerative diseases. Identifies and manages collaborations with contract research organizations and academic labs for the transfer of translational biomarker assays, method development, validation, and clinical execution. Serves as key contributor to preclinical study reports and documents to support Regulatory (IND/ CTA) filings, Investigator Brochures, and clinical study protocols and lab manuals. Works effectively with cross-functional program and development teams to lead programs and strategically progress the pipeline (this includes Go/ No Go decisions based on quality data from in vivo pharmacology or biomarker-based studies) Mentors leaders, develops staff, and promotes culture of collaboration and teamwork.Qualifications
Established scientific reputation with strong knowledge of statistics in the assessment of disease-relevant in vivo models and biomarker endpoints to support neurodegeneration research and development efforts as evidenced by strong publication record, and relationships with key opinion leaders. Strong leadership experience in initiating xternal science, collaborations, and relationships with academic research teams, CROs, and patient advocacy groups. Demonstrated expertise in, and leader of a team responsible for, in vivo pharmacology in preclinical models and translational human biomarkers using clinical samples. Examples of contributions to exploratory neuroscience target selection and demonstrated ability to use in vitro pharmacology data to drive program decisions and portfolio build. Clear track record of authoring relevant sections of IND/ CTA documents and contributions to clinical protocol design. Demonstrated ability to lead directly and cross-functionally; recruit, mentor, develop, and motivate a team of creative, experienced scientists to deliver program / portfolio decisions. Communicates effectively with leadership, employees, colleagues, leadership teams, and the broader external neuroscience community as evidenced by publications, presentations, inventions, and contributions to regulatory filings for clinical candidates. Confident self-starter with a strong work ethic, who holds self and others accountable in the context of greater portfolio deliverables.Education
Ph.D., with 15+ years of industry/ biotech leadership experience in neurobiology and pharmacology with clear contributions to clinical candidates.
#LI-New Haven, CT
Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com
Arvinas is an Equal Opportunity Employer
-
New Haven, United States Arvinas Full timeVice President, Neuroscience Pharmacology and Translational BiomarkersArvinas is a clinical-stage biotechnology company dedicated to improving the lives of patients suffering from debilitating and life-threatening diseases through the discovery, development, and commercialization of therapies that degrade disease-causing proteins. Arvinas uses its...
-
New Bedford, Massachusetts, United States PharmaEssentia U.S.A. Full timeSenior/Principal Scientist, Translational SciencesJob summary: PharmaEssentia Innovation Research Center (PIRC) is seeking a highly motivated and experienced senior or principal scientist to join our Translational Sciences team and contribute to the development of first-in-class and best-in-class biotherapeutics, including cytokines, antibodies, and...
-
Senior Vice President of Operations
2 weeks ago
New York, New York, United States Friends of the Israel Defense Forces Full timePosition OverviewThe Friends of the Israel Defense Forces (FIDF) is a humanitarian nonprofit organization dedicated to providing transformative support to the brave individuals serving in the Israel Defense Forces (IDF). Our mission is to enhance their lives through impactful educational, financial, wellness, and cultural initiatives, ensuring the security...
-
Vice President of IT
3 months ago
New York, United States Knowhirematch Full timeJob DescriptionJob DescriptionVice President of Information Technology - Data Management, Reporting, and Networking (Hybrid, NYC)Position OverviewJoin our dynamic team as the Vice President of Information Technology, where you'll lead our data management, reporting, and computer networking initiatives. This hybrid role requires at least two days on-site...
-
Vice President of IT
4 weeks ago
New York, United States Knowhirematch Full timeJob DescriptionJob DescriptionVice President of Information Technology - Data Management, Reporting, and Networking (Hybrid, NYC)Position OverviewJoin our dynamic team as the Vice President of Information Technology, where you'll lead our data management, reporting, and computer networking initiatives. This hybrid role requires at least two days on-site...
-
Vice President of IT
1 month ago
New York, United States Knowhirematch Full timeJob DescriptionJob DescriptionVice President of Information Technology - Data Management, Reporting, and Networking (Hybrid, NYC)Position OverviewJoin our dynamic team as the Vice President of Information Technology, where you'll lead our data management, reporting, and computer networking initiatives. This hybrid role requires at least two days on-site...
-
Vice President of Hospitality Services
2 weeks ago
New Haven, Connecticut, United States Yale School of Medicine Full timePosition Overview: Vice President of Hospitality ServicesThe Yale School of Medicine is seeking a seasoned professional to assume the role of Vice President of Hospitality Services. This executive will be responsible for managing all facets of hospitality operations, ensuring exceptional experiences for all stakeholders including students, faculty, and...
-
Vice President of Hospitality Services
1 week ago
New Haven, Connecticut, United States Yale School of Medicine Full timeVice President of Hospitality Services at Yale School of MedicineYale School of Medicine is seeking a seasoned professional to take on the role of Vice President of Hospitality Services. This position will be responsible for managing all facets of hospitality operations within the institution, ensuring exceptional experiences for students, faculty, staff,...
-
Vice President of Hospitality Services
1 week ago
New Haven, Connecticut, United States Yale School of Medicine Full timeVice President of Hospitality Services at Yale School of MedicineYale School of Medicine is seeking a seasoned professional to take on the role of Vice President of Hospitality Services. This leader will be responsible for managing all facets of hospitality operations within the institution, ensuring exceptional experiences for all guests, including...
-
New Haven, United States Albertus Magnus College Full timePosition Title: Administrative Assistant to the Vice President for Enrollment Management Reporting to : Vice President for Enrollment Management About Albertus Magnus College: Albertus Magnus College thrives as a diverse and dynamic institution serving 1,500 students in three distinct degree programs: traditional undergraduate, accelerated adult...
-
Senior Associate Biomarker Assay Scientist
20 hours ago
New Haven, United States Pfizer Full timeWhy Patients Need You Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or...
-
Senior Associate Biomarker Assay Scientist
2 days ago
New Haven, United States Pfizer Full timeWhy Patients Need You Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or...
-
New York, New York, United States Maimonides Medical Center Full timeExecutive Vice President of Medical OperationsEXCEPTIONAL CAREER OPPORTUNITY.AT BROOKLYN'S PREMIER HEALTHCARE ORGANIZATION.MAIMONIDES: RECOGNIZED AMONG THE TOP TEN IN THE U.S. FOR CLINICAL OUTCOMES.Maimonides Health stands as Brooklyn's largest healthcare provider, catering to over 250,000 patients annually through its three hospitals, 1,800 medical...
-
Senior Vice President of Advocacy
1 week ago
New Haven, Connecticut, United States All Our Kin LLC Full timePosition Overview****APPLICATION REQUIREMENTS: RESUME AND COVER LETTER REQUIRED****Position Title: Senior Vice President of Advocacy & Community DevelopmentReports to: Chief Strategy OfficerPosition Status: Full-TimeLocation: Remote; travel may be requiredAbout All Our KinAll Our Kin is a national nonprofit organization dedicated to training, supporting, and...
-
New Haven, Connecticut, United States Albertus Magnus College Full timeAbout the RoleAlbertus Magnus College is seeking a highly organized and detail-oriented Administrative Assistant to support the Vice President for Enrollment Management. This is an exciting opportunity to join a dynamic team and contribute to the college's mission of providing exceptional educational experiences.Key ResponsibilitiesSchedule and manage the...
-
Vice President of Residential Services
1 month ago
West Haven, Connecticut, United States Marrakech, Inc. Full timeVice President of Residential ServicesWest Haven, CT 06516, USA Req #1975 Sunday, August 11, 2024Marrakech is looking for staff to work with our wonderful participants with developmental disabilities, physical, behavioral or other needs in a group home setting. We seek nurturing people who will provide care with respect and dignity as well as promote...
-
Vice President of Sales
2 weeks ago
New York, New York, United States The Ladders Full timeAbout the Role: Position: Vice President of Sales - BFSI Type: Full TimeKey Responsibilities:Serve as a trusted advisor to executive leadership, guiding them in enhancing their digital strategies through top-tier infrastructure, platforms, data, and industry-specific solutions. Conduct thorough research on potential and current clients to gather account...
-
Vice President of Private Equity
2 weeks ago
New York, New York, United States Selby Jennings Full timeVice President of Private Equity:A prominent firm specializing in industrial investments within the Middle Market is seeking to fill the role of Vice President. With assets under management exceeding $600 million, this organization boasts a robust history of providing significant returns to its investors and has effectively raised and allocated multiple...
-
Associate Vice President
5 days ago
New York City, United States Manhattan School of Music Full timeAspen Leadership Group is proud to partner with Manhattan School of Music in the search for an Associate Vice President of Philanthropy/Director of Development.Reporting to and working in close collaboration with the Vice President for Philanthropy, the Associate Vice President of Philanthropy/Director of Development will oversee the day-to-day management of...
-
Vice President of Residential Services
1 month ago
West Haven, United States Marrakech, Inc. Full timeVice President of Residential Services West Haven, CT 06516, USA Req #1975 Sunday, August 11, 2024 Marrakech is looking for staff to work with our wonderful participants with developmental disabilities, physical, behavioral or other needs in a group home setting. We seek nurturing people who will provide care with respect and dignity as well as...
