Associate Director/ Senior Principal Scientist, ADME/PK

Found in: Jooble US O C2 - 2 weeks ago

San Francisco CA, United States Oric Pharmaceuticals, Inc. Full time

We are seeking a highly motivated Senior Principal Scientist/Associate Director specialized in characterizing the in vitro and in vivo ADME/PK properties of small molecule lead compounds and drug candidates. This person will work on ORIC drug discovery and development project teams with the goal of developing therapeutics to overcome resistance in cancer. The successful candidate will thrive in partnership with discovery and development teams to identify clinical candidates and support regulatory filings, as well as manage and mentor team members.
Provide interpretation of in vitro, ex vivo and in vivo data that are generated both internally and with CROs; review and interpret bioanalytical data and reports; Participate and contribute to project team meetings and presentations; Manage and mentor scientists, including problem-solving for methods and instrumentation.
* Coauthor and review high quality regulatory documents and DMPK study reports.
* PhD and PostDoc in Pharmacokinetics, Chemistry, Drug Metabolism, Pharmaceutical Sciences or other relevant field with 10+ years of industry experience.
* Strong scientific and technical knowledge in ADME profiling, drug metabolism, transport, SAR analysis and PK; hands on experience in operation and troubleshooting of HPLC and high-resolution mass spectrometers preferred.
* Experience in performing PK analysis using Phoenix or similar; Significant experience in PK/PD analysis, data interpretation and simulation.
* Proficiency in managing collaborations with CROs.
* Track record in mentoring and managing direct reports
* Effective in multidisciplinary project teams and enjoys interacting with colleagues across functions.
*

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