Director, DMPK

3 weeks ago

San Francisco, United States Eli Lilly and Company Full time

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

At DICE Therapeutics, a wholly owned subsidiary of Eli Lilly & Company, we design and develop innovative therapies in immunology for patients with debilitating disease. Seeking to create a future where convenient oral medicines with biologic-like efficacy are available to patients with serious medical conditions, we are developing oral alternatives to medicines currently limited to injectable forms.Responsibilities:

We are currently seeking a Director, Drug Metabolism and Pharmacokinetics, who will have scientific oversight of one or more of the small molecule discovery projects and will manage the in vitro and in vivo PK, ADME and bioanalytical assays. The candidate will be expected to collaborate with Medicinal Chemistry and Pharmacology to develop and implement studies vital to address key program DMPK issues and successfully advance research compounds into development.

Do you have experience as a DMPK Project Leader? Apply today to join the Lilly team

  • Provide scientific DMPK leadership and strategic direction to research project teams
  • Offer scientific supervision for PK/ADME studies conducted at CROs
  • Contribute to and influence the DMPK components in the screening funnel and criteria for compound selection and advancement in research programs
  • Implement/manage quantitative bioanalysis of plasma and other biological matrices to support pharmacokinetic, toxicokinetics, and in vitro ADME analyses of novel small molecule therapeutics
  • May supervise DMPK scientists
  • Conduct PK and PK/PD modeling using non-compartmental and compartmental models
  • Responsible for reviewing BA and TK reports from nGLP and GLP tox studies
  • Organize and maintain research data
  • Present data at project team meetings
  • Guarantee the prompt completion and review of high-quality DMPK reports
  • Contribute to nonclinical PK/ADME sections in regulatory documents (e.g., IB, IND, etc…)Basic Requirements:
  • PhD in a relevant scientific field
7-10+ years of work experience in Drug Discovery/Development DMPKAdditional Skills/Preferences:Strong publication record in the area of ADME/PK coupled with a high level of scientific curiosity and analytical thinking skillsPrior success demonstrating strong leadership, collaboration and influence throughout the organizationPrior management experience is a plusExperience in coordination of in vitro metabolism, DDI, transporters and/or protein binding studiesExperience in performing or supervising the execution of bioanalytical assays and the development of such assaysFamiliar with ABI Analyst, Excel, WinNonlin Phoenix and PrismCapable of working autonomously and collaboratively in a multidisciplinary team settingStrong verbal, written communication and relationship skills including success managing external vendorsExcellent interpersonal and organizational skillsMeticulous and have an in-depth understanding of industry trendsSuccess operating in a fast-paced, dynamic environment

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( Lilly_Recruiting_Compliance@lists.lilly.com ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and help our company develop talented individuals for future leadership roles. Our current groups include: Africa, Middle East, Central Asia Network, African American Network, Chinese Culture Network, Early Career Professionals, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinos at Lilly, PRIDE (LGBTQ + Allies), Veterans Leadership Network, Women’s Network, Working and Living with Disabilities. Learn more about all of our groups.

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