Jobs for senior python backend at New York

10,000 senior python backend job listings in United States. Find daily updated positions from leading job boards.


  • New York, NY, United States Tetrix Inc. Full-time $120,000 - $150,000

    Tetrix Inc. in New York is searching for an experienced Backend Engineer to build and lead core backend infrastructure and services using Python. This role involves designing scalable APIs and robust data ingestion pipelines. The ideal candidate should have at least 10 years of experience in backend engineering, strong technical leadership skills, and a...


  • New York, NY, United States Blackfluo.ai Remote Full-time $100,000 - $140,000

    A tech company is looking for a Senior Full-Stack Developer focusing on backend Python. This remote role requires leading innovative application design, with 5+ years of software development experience, primarily in backend technologies. Candidates should possess strong problem-solving skills and the ability to collaborate effectively in a distributed team....


  • New York, NY, United States Neara Full-time $180,000 - $220,000

    Alaffia Health, a healthcare AI startup in New York City, is seeking a Senior Python Backend Engineer to build and scale AI-powered backend systems. You will design, develop, and deploy data-intensive Python services in production environments, shaping the GenAI framework for the engineering team.You will work in a hybrid model with cutting-edge AI...


  • New York, NY, United States Tetrix Inc. Full-time $100,000 - $130,000

    Tetrix Inc. is seeking a skilled backend developer to build scalable services and data models primarily in Python. The ideal candidate will have over 5 years of experience in data-heavy environments and strong skills in asynchronous Python and APIs. This role emphasizes collaboration with clients and team mentoring while ensuring best practices in B2B SaaS...


  • New York, NY, United States Neara Full-time $180,000 - $220,000

    Senior Python Engineer (Backend) Job type: Full Time · Department: EPD · Work type: Hybrid · USD 180,000-220,000 / year New York, New York, United States Alaffia & Our Mission Every year, U.S. health plans lose billions to improper payments and administrative waste. That wasted spending ultimately trickles down across the healthcare ecosystem, driving up...


  • New York, NY, United States Atlas Search Full-time $120,000 - $190,000

    Atlas Search, a leading talent partner for financial services tech, is seeking a Python Developer to support a next-generation Valuation Workbench platform. You will design backend services, build REST APIs, and help modernize legacy workflows for enterprise-grade systems.The role emphasizes scalable data processing, integration with Snowflake, and...


  • New York, NY, United States Tetrix Full-time $100,000 - $130,000

    A fast-growing startup in New York is seeking a proactive team member with 5+ years of Python experience. This role involves contributing to their tech stack, shaping product direction, and engaging with clients. The ideal candidate is adaptable, customer-oriented, and enjoys collaboration. This position offers a competitive salary, meaningful equity, and an...


  • New York, NY, United States SCALIS Remote Full-time $120,000 - $180,000

    Bold Business, an AI-first U.S.-based company, is hiring a Senior Python Engineer who can own both backend systems and the data layer behind them. You will build production APIs, design pipelines, and ensure the data powering AI systems is clean and reliable, sitting between backend and data under a Lead Architect.You’ll own end-to-end data pipelines,...


  • New York, NY, United States Alignerr Full-time $82,656 - $123,984

    Alignerr is seeking a senior backend engineer to build and lead Python-driven data pipelines, annotation tooling, and evaluation infrastructure for AI systems. The role is an hourly contract with remote work, requiring 20–40 hours per week.You will design APIs, schemas, and auth systems while guiding code reviews and architecture decisions across model...


  • New York, NY, United States Alignerr Full-time $82,656 - $137,760

    Alignerr is seeking a Backend Developer — Data Annotation Systems (AI Training) to design and build data pipelines, annotation tooling, and evaluation systems that power leading AI labs. This fully remote hourly contract role requires 20–40 hours per week and emphasizes high-impact, production-grade Python engineering.You will create scalable backend...


  • New York, NY, United States Citi Full-time

    Python Backend development Assistant Vice presidentApply (opens in new window)Job Req Id:26955046Location(s):Chennai, Tamil Nadu, India, Pune, Maharashtra, IndiaJob Type:On-Site/ResidentPosted:Apr. 20, 2026Discover your future at CitiWorking at Citi is far more than just a job. A career with us means joining a team of more than 230,000 dedicated people from...


  • New York, NY, United States Datasite Full-time $141,000 - $248,000

    Datasite is looking for a Senior Backend Engineer (Python/API) to join the team at Blueflame AI in New York City. This hybrid position requires at least 8 years of experience in software engineering, with a strong focus on Python and RESTful APIs.The role involves collaborating with product and client success teams to develop high-quality software solutions...


  • New York, NY, United States Tetrix Full-time $120,000 - $150,000

    A fast-growing startup in New York is seeking an experienced Backend Engineer to lead the development of core infrastructure and new features using Python. This role involves shaping product direction, collaborating with clients, and mentoring a backend team. Candidates should have over 8 years of experience in backend engineering and strong technical...


  • New York, NY, United States ESR Healthcare Full-time $120,000 - $150,000

    Senior Python Backend-Heavy Full Stack AI Engineer New York, NY (Onsite) We are hiring a Senior Python Backend-Heavy Full Stack AI Engineer with hands‑on experience in LangGraph and agentic AI systems. This role focuses on building production‑grade AI agents and workflows on top of enterprise datasets and internal applications. The ideal candidate is...

  • Senior Python

    6 days ago


    New York, NY, United States Compugain Full-time $100,000 - $130,000

    Compugain in New York is seeking a skilled Developer to implement and maintain back‑end processes in Python 3+. You will integrate with AWS services and design a web interface using Angular JS. The role requires participation in the entire software lifecycle and Agile development.Candidates should have at least 10 years of tech experience, strong knowledge...


  • New York, NY, United States ESR Healthcare Full-time $120,000 - $150,000

    A technology-driven healthcare company based in New York is seeking a Senior Python Backend-Heavy Full Stack AI Engineer to develop production-grade AI agents and workflows. The ideal candidate will have a strong proficiency in Python, experience with FastAPI, and hands-on skills in LangGraph. Responsibilities include building AI solutions, implementing RAG...


  • New York, NY, United States Tetrix Inc. Full-time $100,000 - $130,000

    Overview Tetrix is a fast‑growing startup on a mission to empower institutional investors to confidently invest in alternative markets (think Bloomberg, but for private markets). Our AI-native product transforms messy, unstructured private market data into real‑time insights, combining automated document retrieval, AI‑powered data extraction, and...


  • New York, NY, United States TechWish Full-time $140,000 - $200,000

    TechWish is seeking a Senior Backend (Python) Engineer to design, develop and maintain robust backend services for data-driven decisioning platforms. You will work with a cross-functional team including Scrum Master, Cloud Engineers, AI/ML Engineers and UI/UX Engineers to deliver end-to-end solutions.You will own API design, data handling, and performance...

  • Python/SQL/Backend Developer Premium

    10 hours ago


    New York, New York, United States TecTammina Full-time

    Company DescriptionFirst IT SolutionsJob DescriptionA successful candidate must be comfortable in UNIX shell and in scripting languages such as Python, Perl, Ruby or PowerShell, with 10 years of programming 5 years backend experience including SQL development must have been a significant party in multiple successful enterprise project...


  • New York, NY, United States Tetrix Inc. Full-time $120,000 - $150,000

    Overview Tetrix is a fast‑growing startup on a mission to empower institutional investors to confidently invest in alternative markets (think Bloomberg, but for private markets). Our AI‑native product transforms messy, unstructured private market data into real‑time insights, combining automated document retrieval, AI‑powered data extraction, and...