Scientist, Protein Therapeutics
2 weeks ago
Gilead's mission is to discover, develop, and deliver therapies that will improve the lives of patients with life-threatening illnesses worldwide. The Protein Engineering group is a specialized team within the Protein Therapeutics department that is responsible for the optimization and engineering of large molecule drug candidates. We seek a highly motivated Scientist in Protein Therapeutics to contribute to the engineering of novel antibody binding domains, fusion proteins (e.g. cytokines), and multispecific formats. The successful candidate will support cross-functional project teams to develop novel biologics for clinical development. In this laboratory-based role, the successful candidate will support efforts to optimize large molecule therapeutics. The candidate will implement structure-based design and molecular biology approaches to rapidly generate engineered large molecule therapeutics for diverse target classes. Additional job requirements: Drive rapid optimization of novel antibody and protein therapeutics through iterative design, build, test, and learn cycles. Advance engineering technologies to enable development of novel antibodies, multispecifics, immunocytokines, and other biologics. Characterize the binding and functional properties of large molecule drugs. Interpret protein structural models to aid in rational protein design. Represent the Protein Therapeutics department on inter-disciplinary project teams and guide preclinical development of large molecule therapeutics. Maintain familiarity with scientific literature and independently design, execute, analyze, and interpret experiments. Effectively communicate and present project goals and experimental findings to diverse audiences. Organize and execute multiple projects in a collaborative team setting. Thrive in a fast-paced, data-driven and scientifically rigorous environment. Maintain compliance with company policies and record keeping. Basic Qualifications Applicants must have a degree in structural biology, biochemistry, molecular biology or a related field. Bachelor's Degree and Seven Years Experience OR Masters' Degree and Five Years Experience OR Ph.D. and Zero to Three Years of Relevant Professional Experience Preferred Qualifications Ideal candidate will have experience in most of the following areas: Experience with multispecific antibody format design, including design of fusion proteins (e.g. immunocytokines, etc). Proficient in mammalian cell culture, protein expression, purification, and characterization. Proficiency with structure-based (e.g. PyMOL, MOE, Chimera, AlphaFold, ImmuneBuilder, etc) protein engineering and design is required. Experience using computational design software (e.g. Rosetta, MPNN, etc) is a plus. Familiarity with in vitro protein biophysical characterization approaches (e.g. Octet, Carterra, SPR, FACS, etc). Proficient in molecular biology techniques (e.g. PCR fragment assembly, vector design, and site-directed mutagenesis). Familiarity with antibody engineering, including experience with antibody variable domain reformatting, humanization, sequence liability remediation, and/or biophysical property improvement. Excellent communication and organizational skills. Ability to multi-task and self-motivated with excellent problem-solving skills. #J-18808-Ljbffr
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Sr Scientist, Protein Therapeutics
2 weeks ago
Foster City, United States Gilead Sciences, Inc. Full timeGilead Research is looking for an experienced proteomics scientist to join the Mass Spectrometry group in the Protein Therapeutics department. The successful candidate will collaborate with project teams and therapeutic areas as a subject matter expert, assist in study design, data analysis and results interpretation, in addition to managing experiments....
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Principal Scientist, Protein Therapeutics
2 weeks ago
Foster City, United States Gilead Sciences, Inc. Full timeDescription The Biologics Engineering group is a specialized team within the Protein Therapeutics department that is responsible for the optimization and engineering of large molecule drug candidates. We seek a highly motivated Principal Scientist to contribute to the engineering of Multispecific formats, novel antibody binding domains, fusion proteins...
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Protein Therapeutics Scientist: Antibody
2 weeks ago
Foster City, United States Gilead Sciences, Inc. Full timeAn established industry player is seeking a dedicated Scientist in Protein Therapeutics to join a specialized team focused on optimizing large molecule drug candidates. This role involves implementing structure-based design and molecular biology techniques to engineer novel antibody binding domains and fusion proteins. The ideal candidate will thrive in a...
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Principal Scientist, Protein Therapeutics
2 weeks ago
Foster City, United States Gilead Sciences Full timeAt Gilead, we're creating a healthier world for all people. For more than 35 years, we've tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer - working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world's biggest health challenges, and our...
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Principal Scientist, Protein Therapeutics
7 days ago
Foster City, CA, United States Gilead Sciences Full timeAt Gilead, we're creating a healthier world for all people. For more than 35 years, we've tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer - working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world's biggest health challenges, and our...
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Principal Scientist, Protein Therapeutics
1 week ago
Foster City, CA, United States Gilead Sciences Full timeAt Gilead, we're creating a healthier world for all people. For more than 35 years, we've tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer - working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world's biggest health challenges, and our...
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Principal Scientist, Protein Therapeutics
7 days ago
Foster City, CA, United States Gilead Sciences Full timeAt Gilead, we're creating a healthier world for all people. For more than 35 years, we've tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer - working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world's biggest health challenges, and our...
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Principal Scientist, Protein Therapeutics
2 weeks ago
Foster City, CA, United States Gilead Sciences Full timeAt Gilead, we're creating a healthier world for all people. For more than 35 years, we've tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer - working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world's biggest health challenges, and our...
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Principal Scientist, Protein Therapeutics
2 days ago
Foster City, United States Gilead Sciences, Inc. Full timePh.D. in biochemistry, structural biology or a related field with 6+ years (postdoctoral training preferred) **OR** M.S. with 8+ years (16+ years preferred) **OR** B.S. with 10+ years (18+ years preferred) of additional experience in an academic or industrial setting and a record of accomplishments in the form of high impact publications or patents*...
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Senior Protein Therapeutics Scientist
4 days ago
Foster City, United States Gilead Sciences, Inc. Full timeA leading biotechnology firm in California is seeking a highly motivated Sr. Research Associate to join their protein therapeutics team. This role involves performing protein purification, QC, and collaborating with research teams to develop therapeutic proteins. Required qualifications include a degree in a relevant field, strong background in protein...
