Principal Scientist, Protein Therapeutics

At Gilead, we're creating a healthier world for all people. For more than 35 years, we've tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer - working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world's biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference. Every member of Gilead's team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we're looking for the next wave of passionate and ambitious people ready to make a direct impact. We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together. Job Description The Biologics Engineering group is a specialized team within the Protein Therapeutics department that is responsible for the optimization and engineering of large molecule drug candidates. We seek a highly motivated Principal Scientist to contribute to the engineering of Multispecific formats, novel antibody binding domains, fusion proteins (e.g. cytokines), as well as to the development of new, cutting-edge technologies. The successful candidate will independently oversee biologics projects from protein design to lead optimization, manage multiple discovery projects, and advance engineering technologies to enable large molecule drug development. Gilead Sciences Inc. is a highly matrixed organization. Effective collaboration across multiple function groups is an important attribute of this role. Responsibilities: Lead a small team of protein engineers to help design and engineer innovative protein therapeutics to address unmet medical needs through differentiated mechanisms of action Drive rapid optimization of novel antibody and protein therapeutics through iterative design, build, test, and learn cycles Represent the Protein Therapeutics department on interdisciplinary project teams and guide preclinical development of large molecule therapeutics Independently carry out lead sequence optimization of large molecules utilizing rational and in silico design approaches, as well as design of multispecifics, immunocytokines, and fusion proteins Communicate transparently and timely to key stakeholders to build strong partnership and collaboration experiences Thrive in a fast paced, data-driven, and scientifically rigorous environment Maintain compliance with company policies and record keeping Basic Qualifications: Ph.D. in biochemistry, structural biology or a related field with 6+ years (postdoctoral training preferred) OR M.S. with 8+ years (16+ years preferred) OR B.S. with 10+ years (18+ years preferred) of additional experience in an academic or industrial setting and a record of accomplishments in the form of high impact publications or patents Preferred Qualifications: Extensive experience advancing protein therapeutics from discovery to development and stays abreast with emerging protein engineering platforms and technologies Expertise in structure-based protein engineering and design of multispecifics, immunocytokines, Fc engineering, and fusion proteins Skilled practitioner in antibody engineering, including humanization, sequence liability remediation, and/or biophysical property improvement Project leadership experience in Research across multiple therapeutic areas, with deep understanding of hit-to-lead selection through preclinical development of therapeutic candidates Presentation and high impact publication record with demonstrable protein engineering expertise Proficient in various molecular biology and/or library building techniques (e.g. PCR fragment assembly, vector design, site-directed mutagenesis, Gibson assembly, and/or Golden gate cloning), as well as hands-on experience (preferred) with mammalian cell culture, protein expression, purification, and characterization; in vitro and in vivo antibody discovery approaches is a plus Experience with computational design tools preferred (e.g. Rosetta, MOE, or DiscoveryStudio) Team player with strong collaboration, communication, organizational skills, and excellent problem-solving skills The salary range for this position is: $195,670.00 - $253,220.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans*. For additional benefits information, visit: https://www.gilead.com/careers/compensation-benefits-and-wellbeing Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans. For jobs in the United States: Gilead Sciences Inc. is committed to providing equal employment opportunities to all employees and applicants for employment, and is dedicated to fostering an inclusive work environment comprised of diverse perspectives, backgrounds, and experiences. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, sex, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact ApplicantAccommodations@gilead.com for assistance. For more information about equal employment opportunity protections, please view the 'Know Your Rights' (https://www.eeoc.gov/employers/eeo-law-poster) poster. NOTICE: EMPLOYEE POLYGRAPH PROTECTION ACT (http://www.dol.gov/whd/regs/compliance/posters/eppac.pdf) YOUR RIGHTS UNDER THE FAMILY AND MEDICAL LEAVE ACT Gilead Sciences will not discharge or in any other manner discriminate against employees or applicants because they have inquired about, discussed, or disclosed their own pay or the pay of another employee or applicant. However, employees who have access to the compensation information of other employees or applicants as a part of their essential job functions cannot disclose the pay of other employees or applicants to individuals who do not otherwise have access to compensation information, unless the disclosure is (a) in response to a formal complaint or charge, (b) in furtherance of an investigation, proceeding, hearing, or action, including an investigation conducted by the employer, (c) consistent with the legal duty to furnish information; or (d) otherwise protected by law. Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team. Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion. For Current Gilead Employees and Contractors: Please apply via the Internal Career Opportunities portal in Workday. Gilead Sciences, Inc. is a biopharmaceutical company that has pursued and achieved breakthroughs in medicine for more than three decades, with the goal of creating a healthier world for all people. The company is committed to advancing innovative medicines to prevent and treat life-threatening diseases, including HIV, viral hepatitis and cancer. Gilead operates in more than 35 countries worldwide, with headquarters in Foster City, California.