Director, In Vivo Pharmacology

3 weeks ago

Somerville, United States Cellarity Full time

What if you could join a rapidly growing company and play a critical role in bringing new medicines to patients through looking at and treating disease in a revolutionary way.


What this position is all about:

Cellarity is seeking an energetic, talented and highly motivated Director/Assoc Director to lead our In Vivo Pharmacology department and play a vital role in the company’s efforts to progress small molecule lead candidates to IND. The candidate will be responsible for internal and external in vivo studies in rodent (and non-rodent) species. The successful candidate will represent in vivo pharmacology in program teams to rapidly advance Cellarity’s drug discovery programs. S/he will be comfortable working in and contributing to a highly dynamic and cross-functional team environment. The ideal candidate must be independent, driven, open-minded, curious, goal-oriented, have excellent communication skills and work in a fast-paced entrepreneurial environment.


What you would be responsible for:

  • Lead and manage the In Vivo Pharmacology team in performing critical preclinical efficacy studies across different clinical indications.
  • Design, execution, and analysis of pharmacology studies to support the advancement of candidates along the developmental pipeline.
  • Identify, initiate, and manage collaborations with CROs and academic labs as appropriate to driving projects forward.
  • Provide strategic input to project teams.
  • Integrate data to provide a detailed understanding of the pharmacology of therapeutic proteins to enable understanding of in vitro MOAs and in vivo correlates of efficacy.
  • Establish biomarker strategies to support translational studies.
  • Implement procedures for data capture and management.
  • Support preparation of regulatory documents as needed.
  • Maintain scientific and technical expertise through familiarity with scientific literature.
  • Contribute to building a positive, team-oriented biotech culture.


What experiences will you need:

  • PhD in pharmacology or biological disciplines such as immunology, cellular biology, or oncology, with 8+ years direct pharmaceutical experience beyond postdoctoral work.
  • In depth in vivo pharmacology experience, particularly on the design and execution of rodent disease models across broad clinical indications. Experience in hematology and autoimmune models is a plus.
  • Demonstrated leadership of teams of in vivo scientists to drive go/no go decisions.
  • Extensive experience in managing the design and execution of studies at CROs.
  • History of translational sciences support for preclinical small molecule programs.
  • Ability to manage priorities and drive multiple projects.
  • Direct experience in supporting IND strategy and documentation, including writing relevant pharmacology sections of INDs.
  • Excellent oral and written communication skills across all levels.
  • Prior experience working in smaller companies is highly preferred.


What sets you apart:

  • Passion to develop drug candidates to make an impact in patients’ lives.
  • Willingness to go beyond expectations to achieve critical objectives.
  • Recognition of critical path activities required to succeed in drug discovery

What it’s like to work at Cellarity:


At Cellarity, we

  • Push Boundaries: We create a legacy with breakthrough science in service of patients.
  • Inject Energy: We build strengths from different perspectives and tell it like it is
  • Own it: We transcend our job descriptions and relentlessly follow through on our commitments.
  • Go all out: We work quickly and with conviction.

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