Associate Director/Director Medicinal Chemistry

4 weeks ago

Boston, United States Kestrel Therapeutics Full time

Associate Director/Director, Medicinal Chemistry


At Kestrel, our mission is to invent cutting-edge technologies and develop novel small molecule agents targeting critical cancer pathways. Our focus is on mutant RAS, cancer’s most frequently mutated oncogenic target. We are committed to rigorously applying innovative science to discover new medicines for cancer patients. Our top priority is always the patients we serve. Kestrel is an oncology biotech start-up, actively growing since launching in January 2022. We are currently expanding our team to advance our pioneering research and development efforts.

We are currently seeking an outstanding individual to lead Kestrel’s medicinal chemistry activities. This role is expected to effectively design small molecules, manage a team of contract chemists, and excel in a collaborative multidisciplinary environment.


Key Responsibilities

  • Lead integrated medicinal chemistry projects from hit generation through the lead optimization process.
  • Manage project specific resources including external chemistry personnel.
  • Must show keen attention to timelines to rapidly advance projects and achieve program goals.
  • Plan, execute, interpret, and optimize structure activity relationship campaigns.
  • Plan complex chemical syntheses as needed to deliver high quality molecules for biological screening.
  • Develop new IP and lead the preparation of project specific patent documents as appropriate.
  • Build and maintain productive relationships with internal and external collaborators in biology, pharmacology, computational chemistry, DMPK, toxicology, and early development.
  • Ability to clearly and effectively communicate project updates to key stakeholders.

Professional Experience & Qualifications

  • Ph.D. in Organic Chemistry or related field with 5+ years of experience working in a pharmaceutical / biotechnology setting as a medicinal chemist.
  • Demonstrated leadership in medicinal chemistry and drug discovery as evidenced by a strong record of scientific accomplishment and cross-functional collaboration.
  • Outstanding synthetic chemistry background and a demonstrated track record of aptitude and problem solving in medicinal chemistry.
  • Demonstrated experience delivering compounds from hit to IND.
  • Experience in working with CRO partners and proven ability to work efficiently in a hybrid research model.
  • Excellent written and oral communication skills.
  • Self-motivated, enthusiastic, and able to expeditiously change course as part of working in a dynamic, interdisciplinary setting.
  • Good interpersonal skills.

At Kestrel we adhere to the following Guiding Principles:

  • Care: Be patient-focused and commit to making new medicines
  • Integrity: Be honest, accountable, and conscientious
  • Intelligence: Be smart, curious, and critical
  • Teamwork: Be collaborative and work in partnership to achieve shared goals
  • Tenacity: Be determined, disciplined, and relentless
  • Discovery: Be innovative and inventive


Kestrel Therapeutics offers a generous benefits package including medical, dental, vision, and disability insurance, as well as paid time off and a 401k plan.

Kestrel Therapeutics is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, ethnicity, color, national origin, religion, age, marital status, veteran status, disability, genetic information, sexual orientation, gender identity or any other basis protected by federal, state, or local law.

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