Senior Process Chemistry Director

4 weeks ago


Boston, Massachusetts, United States BioSpace, Inc. Full time
Job Summary

The Associate Director, Process Chemistry will be responsible for the design, development and staffing of the RNAi Chemical Development capability at Dicerna and Novo Nordisk. This role will lead the development, optimization, and scale up of biocatalytic and traditional synthetic processes to successfully transfer production internally or at external CMO's.

Key Responsibilities

Lead the development, optimization, and scale up of biocatalytic and traditional synthetic processes to successfully transfer production internally or at external CMO's
Develop, mentor, and lead a team of process development chemists and engineers
Oversee the efficient utilization of a kilo lab pilot facility
Direct development and scale-up of liquid phase batch processes used to generate small molecules, oligonucleotide Intermediates, and API's
Analyze research data to identify and evaluate problems and determine appropriate solutions utilizing an array of analytical techniques
Support regulatory filings as necessary
Support the overall Chemical Development team goals with accurate budget and staff projections

Requirements

A PhD in Chemistry, Chemical Engineering, or related sciences with 8+ years of relevant experience, or MS in Chemistry, Chemical Engineering, or related sciences with 10+ years of relevant experience. Proven track record of experience in process chemistry with demonstrated expertise in the optimization and scale up of pharmaceutically relevant compounds. Well versed in process scale up. Ability to develop, mentor and lead process chemistry teams. Tech transfer experience. Excellent research skills; ability to identify and define problems, develop hypotheses, and develop and execute plans to solve the problem. Outstanding written and verbal communication skills. Strong problem solving and trouble shooting skills.

Preferred Qualifications

Experience with development and characterization of biocatalytic processes. CMO management experience. A deep understanding of and ability to apply of GMP/ICH/FDA regulations to process development strategies for Oligonucleotide based drugs.

What We Offer

Novo Nordisk offers a competitive compensation package, including a base salary range of $150,000 to $185,000, as well as a company bonus based on individual and company performance. Long-term incentive compensation and company vehicles are also available. Employees are eligible to participate in Company employee benefit programs, including medical, dental and vision coverage; life insurance; disability insurance; 401(k) savings plan; flexible spending accounts; employee assistance program; tuition reimbursement program; and voluntary benefits such as group legal, critical illness, identity theft protection, pet insurance and auto/home insurance. The Company also offers time off pursuant to its sick time policy, flexible vacation policy, and parental leave policy.
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