Scientist - III

3 weeks ago

Cambridge, United States TALENT Software Services Full time
Scientist – in-vitro disease modeling
Genome Sciences department in MRL is looking for a motivated scientist to lead the identification and validation of new genetic targets for various cardiometabolic diseases including Type Diabetes (TD), Obesity, Atherosclerosis, Retinal diseases, and vascular diseases. This individual will play a pivotal role as a member of the discovery team, contributing to the development of innovative models for screening drug targets.

Job responsibilities:
• Establish stem cell-based in-vitro disease platforms.
• Design assays using high content imaging techniques to facilitate screening of small molecules and genetic modifications using CRISPR.
• Perform lab experiments, interpret data, and effectively communicate findings.
• Collaborate with cross-functional teams in therapeutic and functional areas.
• Maintain electronic lab notebook and sample inventories.

Qualifications:
Education requirements:
• BS with + years of experience/Masters with + years of experience/PHD with + year of experience in a wet lab setting.
• Candidates with a background in muscle biology will be given preference.

Required experience and skills:
• Skilled in cell culturing and differentiation of stem cells into specific lineages.
• Experience with gene manipulation technologies such as CRISPR, siRNA, ASOs, lentivirus, and AAVs.
• Expertise in molecular biology techniques including RNA extraction, qPCR, ELISA/MSD, and ICC.
• Critical thinking with an ability to formulate experimental strategies.
• Effective in working independently and collaboratively within a team.
• Outstanding verbal and written communication skills.

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