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Research Technician II, Tissue Culture, Molecular Genetics
Why UT Southwestern Medical Center?
With over 75 years of excellence in Dallas-Fort Worth, Texas, UT Southwestern is committed to excellence, innovation, teamwork, and compassion. At UT Southwestern, we invest in you with opportunities for career growth and development that align with your future goals and help to provide security for you and your family. Our highly competitive benefits package offers healthcare, PTO and paid holidays, on-site childcare, wage, merit increases and so much more that are all available on the day you start work. UT Southwestern is honored to be a Veteran Friendly work environment that is home to approximately 800 veterans. We value your integrity, dedication, and the commitment you’ve made to our country. We’re proud to support your next mission. Ranked by Forbes as one of the Top 10 National Employers, we invite you to be a part of the UT Southwestern team where you’ll discover teamwork, professionalism, and consistent opportunities for growth.
Department of Molecular Genetics
The Department of Molecular Genetics applies powerful tools of molecular biology to problems of clinical medicine with heavy emphasis on genetic and metabolic disorders. Identification and characterization of malfunctioning genes in disease can lead not only to better treatment of the disease but also to understanding how the genes operate in the normal state. The Department of Molecular Genetics faculty holds some of science’s highest awards and recognitions:
Two Nobel Laureates Three Howard Hughes Medical Institute Investigators Five National Academy of Sciences members Three National Academy of Medicine (formerly the Institute of Medicine) members
Job Summary
The Drs. Joseph L. Goldstein and Michael S. Brown Lab I seeking a Research Technician II. Our laboratory discovered the SREBPs and described their unique transport-dependent proteolytic activation. We then discovered SCAP the two proteases that process SREBPs, and the role of Insigs as ER retention proteins. We are exploring the molecular mechanisms by which cholesterol, fatty acids, and insulin control this process. We use experimental systems ranging from protein crystallography to cell biology to animal physiology. Over the years we have trained more than 20 graduate students and 100 postdoctoral fellows, all of whom are pursuing productive careers in biomedical research.
The Research Technician II will be responsible for assisting with the handling and experimental manipulation of various small animal species. This individual will assist in standard molecular cloning such as recombinant DNA, protein expression and purification, as well as tissue culture experiments.
Specific responsibilities include assisting with the handling, experimental methods, tissue collection of mice and rats. Will also assist in molecular biology techniques such as RNA/DNA isolation and purification, protein expression and purification, PCR, SDS PAGE Electrophoresis as well as tissue culture experiments in our study of cholesterol metabolism and homeostasis. Experience with these techniques is optimal, but not required.
Prefer applicant with previous work experience with small animals.
Experience and Education
Bachelor’s degree with major coursework in field of assignment and no experience required. or
Two (2) years college with emphasis in coursework in field of assignment and two (2) years of laboratory experience at level of Laboratory Technical Assistant or equivalent. or
High school graduation or GED and four (4) years laboratory experience to include two (2) years at level of Laboratory Technical Assistant or equivalent.
Job Duties
Performs routine scientific and medical research work in science areas such as biology, chemistry, physics, or other related scientific field. Assembles and/or operates various laboratory equipment and apparatus. Records research data in accordance with prescribed procedures, discussing results with supervisor. Assists in collection of data for project reports. Reads literature and confers with supervisor concerning implementation of new procedures. May plan for, and provide working supervision to, work of laboratory personnel of lower grade engaged in limited phase of research project. Performs other duties as assigned.To learn more about the benefits UT Southwestern offers, visit
UT Southwestern Medical Center is committed to an educational and working environment that provides equal opportunity to all members of the University community. As an equal opportunity employer, UT Southwestern prohibits unlawful discrimination, including discrimination on the basis of race, color, religion, national origin, sex, sexual orientation, gender identity, gender expression, age, disability, genetic information, citizenship status, or veteran status.
