Postdoctoral Associate in Structural Virology

2 months ago


Piscataway, United States Rutgers University Full time

Posting Summary

The Kaelber lab is recruiting a scientist to work on the boundaries of structural biology and virology, using cryo-electron microscopy to answer fundamental questions in viral gene delivery and infection of mammalian cells, and to contribute toward structure-based rational design of viral nanotechnologies such as gene therapy vectors. This position will involve significant collaborations with scientists in academia and industry. Training will be provided in cutting-edge cryogenic ultramicroscopy technologies including cryoFIB. Mentorship of 1-2 undergraduate students will be encouraged. The proposed experimental portfolio is balanced with both low-risk and high-risk experiments. BSL-2 pathogens will be utilized. Areas of specific focus include adeno-associated virus and other mammalian parvoviruses.The candidate will culture and infect cells with recombinant virions and leverage in situ nanoimaging techniques to understand the molecular mechanisms of nuclear entry and uncoating.The Kaelber lab is located in the Institute for Quantitative Biomedicine, home to several experts in cryoEM and in molecular dynamics. The building is shared with the RCSB Protein Data Bank (PDB). Prof. Kaelber also directs the Rutgers New Jersey Cryo-electron Microscopy & Tomography Core Facility, which contains four electron microscopes including North America’s first “Aquilos 2”-model cryogenic focused ion beam/scanning electron microscope as well as a Krios cryoTEM. Position Status Full Time Posting Number 24FA0858 Posting Open Date 09/03/2024 Posting Close Date Qualifications Minimum Education and Experience Terminal degree in life sciences or chemical sciences. Exceptional candidates with 5+ years’ relevant research experience may also be considered at the Research Assistant level. Certifications/Licenses Required Knowledge, Skills, and Abilities At least one of the following is required, but more are preferred:· Excellence in classical and molecular virology· Excellence in biochemistry· Excellence in cryoelectron tomography· Excellence in structural bioinformaticsAdditionally required skills are:· Commitment to ethical conduct of research· Self-motivation and independence· Good documentation habits· Proficiency with Unix command line· A track record of productive, “wet-lab” results Equipment Utilized Cryo-transmission electron microscope; cryo-focused ion beam; cryo-scanning electron microscope; cryo-fluorescence microscope; biosafety cabinet; ultracentrifuge; plate reader; vitrification robot Physical Demands and Work Environment Experiments require fine manual dexterity for manipulation of small objects under cryogenic conditions, and vision in low light conditions. Overview Statement

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