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Operating Principal

2 weeks ago

Boston, Massachusetts, United States Flagship Pioneering, Inc. Full time $265,000 - $330,000

Introduction

Flagship Pioneering is a company that creates companies, building ground-breaking platforms that change the world. We are a brave and bold organization of creative-thinkers with insurgent mindsets and corporate-builders with incumbent expertise.

What if... we could harness the power of data with AI to create breakthroughs and accelerate the creation of new technologies?  This is the question that Flagship Pioneering seeks to explore with our latest AI-focused business unit. Our mission is to create, launch, and scale breakthrough ventures that transform how we live, work, and connect. We build companies from zero to one, with cutting-edge AI, exceptional user experience, and a strong vision to pioneer an AI-native future.

Position summary

As an Operating Principal, you will be the driving force behind a seed to Serie A stage software/tech venture, responsible for validating core hypotheses, shaping early product direction, and helping with initial growth. You'll operate as a de facto Head of Operations - combining strategic vision, executional rigor, and entrepreneurial hustle to turn an early concept into a scalable business. This is a hands-on, high-impact role suited for a builder - someone who thrives in ambiguity, loves iterating on products and go-to-market strategies, and has a deep understanding of what it takes to make early-stage companies succeed.

Key Responsibilities

  • Venture building: own the operational and strategic roadmap of an early-stage venture from idea validation through initial launch and traction.
  • Product-market fit: identify and test hypotheses rapidly through customer discovery, MVP development, and iterative experimentation.
  • Cross-functional leadership: coordinate with research, engineering, and growth teams to build, optimize and iterate software and tech products.
  • GTM strategy: define the target market, business model, and acquisition strategy to create scalable, repeatable growth engines.
  • Talent and culture: recruit early team members and establish the operating culture, processes, and principles. Lead with inspiration and inclusion

Qualifications

  • Experience: 5–10 years in startups, consulting, or venture building - ideally with experience taking software platforms/products from concept to market.
  • Entrepreneurial mindset: Proven ability to thrive in ambiguity, move fast, and execute with limited resources.
  • Product fluency: Strong understanding of user research, MVP development, and data-informed decision-making.
  • Technical literacy: Familiarity with AI technologies (e.g., LLMs, generative AI, or data-driven personalization) and their consumer applications.
  • Leadership: Exceptional communication and cross-functional leadership, proven track record of building teams.
  • Bias for action: A pragmatic problem-solver who can balance strategic vision with operational excellence.

Why join us

  • Build from scratch: Be at the forefront of world-shaping innovations and launch entirely new AI-native companies from scratch.
  • Operate like a founder: Own key decisions, strategy, and execution without the distractions of initial fundraising and administration.
  • Share the upside: Participate in the equity and long-term success of the ventures you help bring to life.

ABOUT FLAGSHIP PIONEERING

Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.  

Flagship has been recognized twice on FORTUNE's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at 

At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact.

We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.

We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

The salary range for this role is $265,000 - $330,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Flagship Pioneering currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Flagship Pioneering's good faith estimate as of the date of publication and may be modified in the future.