Scientist/Senior Scientist

5 days ago

South San Francisco, California, United States Preventive Full time

About the role

Preventive is hiring a Scientist or Senior Scientist to lead genomic analysis across wet‑lab experimentation and computational pipelines. You will design, execute, and analyze ultra‑low‑input NGS experiments from heterogeneous, multi‑species samples with emphasis on epigenetic characterization and comprehensive safety/off‑target profiling. The role spans low‑input method development, specialized library prep, and computational analysis.

Key Responsibilities

  • Safety / off‑target profiling: Genome‑wide assessment of edited samples via WGS (short/long‑read), targeted capture, and GUIDE‑seq/CIRCLE‑seq/CHANGE‑seq derivatives with orthogonal validation; call SNVs/indels/SVs/CNVs and quantify mosaicism/allele‑specific edits.
  • Characterization of edited samples: Execute low‑input NGS (scRNA‑seq/snRNA‑seq, ATAC/scATAC, methylation/WGBS or ONT CpG, long‑read sequencing) on very small, heterogeneous populations.
  • Computational analysis: Build and maintain reproducible analysis pipelines; perform QC, UMI handling, multi‑genome alignment, ambient RNA/doublet removal, batch correction/integration, differential analysis, trajectory/RNA velocity; support cross‑species analyses (liftover/custom references).
  • Experimental design & wet lab: Partner with genome‑editing teams on controls and study design; design guides/donors; perform cloning and trace‑input library prep with rigorous QC and documentation.

Qualifications

Minimum qualifications
  • BS+ in a relevant field (we care more about your experience than your formal education); 2+ years biotech experience.
  • Fluency in R or Python; experience analyzing NGS data (alignment, QC, variant calling) and building reproducible workflows.
  • Demonstrated expertise with low‑input/single‑cell assays (e.g., scRNA‑seq, epigenomic profiling, long‑read).
  • Proficiency in molecular biology (library prep, cloning, PCR/qPCR, nucleic‑acid QC) and sterile mammalian cell culture.
Preferred qualifications
  • End‑to‑end off‑target discovery/validation for gene‑edited samples in preclinical studies, leading to submission to regulatory bodies
  • Single‑cell analysis beyond defaults (batch correction, trajectory/velocity, doublet/ambient handling in low‑cell‑number datasets).
  • Genome‑wide variant analysis for edited samples (SNVs/indels/SVs/CNVs; low‑VAF mosaic detection; integration‑site mapping) and epigenomic characterization.
  • Experience with very early developmental or gamete samples across species.
  • Spatial transcriptomics/epigenomics
  • Previous experience in a startup environment (comfort with fast cycles, evolving priorities, and cross‑functional collaboration).

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