Research Engineer 3

Department Overview

The OHSU Knight Cancer Institute is a world leader in treating leukemia. Our director, Dr. Brian Druker, is an internationally recognized pioneer in precision cancer medicine. Dr. Druker played a central role in developing Gleevec, a daily pill for chronic myelogenous leukemia (CML) that has saved tens of thousands of lives. Now he is helping lead Beat AML, a major effort to find better treatments for acute myeloid leukemia.

Every Knight Cancer employee is expected to embody our guiding principles: 

• We act BOLDLY—Breakthroughs require pushing the boundaries of science, exploring new frontiers, and thinking differently
• We SUPPORT each other—Respect leads to trust, which leads to excellence
• We work as a CONNECTED team—We must leverage our collective brain power to conquer cancer because no one individual can do it alone

Function/Duties of Position

The Research Engineer 3 (RE3) will lead engineering design and execution of high-throughput single-cell combinatorial indexing assays to enable detection of rare cancer cell populations. The RE3 designs, builds, and optimizes multi-omic workflows including: (i) single-cell RNA-seq with targeted genotyping, (ii) multi-level indexing single-cell ATAC-seq with genotyping, (iii) sciMETv3 (single-cell DNA methylation) with RNA-based targeted genotyping, and (iv) novel co-assays integrating these modalities. Responsibilities span assay/system architecture, reagent and indexing schema design, automation and instrumentation, process control, data quality engineering, and documentation/compliance to deliver robust, scalable platforms for rare-cell detection and clonal tracking in hematologic malignancies. Qualified candidates will have expertise in most/all of these domains.

The role requires independent planning and prioritization, meticulous record keeping and data stewardship, and cross-functional collaboration with molecular biologists, computational scientists, and clinical collaborators to achieve project milestones on time and to specification in a fast-paced, project-based environment. Some weekend work is required.

Salary will be commensurate with experience. We are looking for an enthusiastic individual who is capable and willing to make maximum use of excellent facilities and a productive environment.

Required Qualifications

• PhD in Computational Biology or related field OR Master's Degree in Computational Biology or related field AND 6 years of relevant experience Equivalent combination of Bachelor's in relevant field in conjunction with training and experience may be considered
• Experience with at least 3 of the following fields:  electrical/optical setup installation, machining, data processing, biochemistry, molecular biology, nanoparticles and material characterization
• Excellent communication, analytical and organizational skills
• Ability to work independently and as part of a team while being collaborative in resolving problems
• Ability to prioritize multiple tasks at one time
• Must possess energy and drive to coordinate multiple projects simultaneously
• Ability to use tact and diplomacy to maintain effective working relationships

Additional Details

Apply online. Please be sure to upload a Cover Letter and Resume/CV.

We offer a variety of benefits on top of joining a thriving organization:

• Medical, dental and vision coverage at no or low cost to employees
  • Covered 100% for full-time employees and 88% for dependents
• Several retirement plans to choose from with contributions from OHSU
• 25 days a year of paid time off
• 8 days of sick time off
• Commuter subsidies
• Tuition reimbursement
• Access to group life insurance, disability insurance and other supplemental benefits
• Annual Merit Increase
• Growth/Development Opportunities
• Employee discounts to local and major businesses

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All are welcomeOregon Health & Science University values a diverse and culturally competent workforce. We are proud of our commitment to being an equal opportunity, affirmative action organization that does not discriminate against applicants on the basis of any protected class status, including disability status and protected veteran status. Individuals with diverse backgrounds and those who promote diversity and a culture of inclusion are encouraged to apply. To request reasonable accommodation contact the Affirmative Action and Equal Opportunity Department at or

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