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Sr. Manager, Screening
2 weeks ago
PTC Therapeutics is a global commercial biopharmaceutical company. For over 25 years our team has been deeply committed to a unified purpose: Extending life's moments for children and adults living with a rare disease.At PTC, we cultivate an inclusive culture where everyone feels valued, respected, and empowered. We welcome candidates from all backgrounds to join our team, fostering a strong sense of belonging.Visit our website to learn more about our company and cultureSite: Job Description Summary: The Senior Manager, Screening and Compound Management is integral to optimizing high-throughput screening robotic platforms and compound operations, directly supporting drug discovery initiatives. This role ensures the execution of high-quality biochemical and cell-based assays, overseeing vital processes such as compound handling, storage, and screening. By safeguarding the integrity of compound libraries and streamlining workflows, the senior manager accelerates research timelines and delivers essential data for early-stage drug development. Leading a multidisciplinary team, the senior manager fosters a collaborative environment that champions innovation and continuous improvement through the adoption of advanced technologies like automated liquid handling systems and sophisticated data analytics tools.In addition to technical responsibilities, the senior manager engages in strategic planning and resource allocation to address dynamic stakeholder needs, aligning compound management strategies with broader research goals. This involves prioritizing screening campaigns, acquiring new chemical entities, and developing specialized protocols. Collaborating with teams in medicinal chemistry, biology, and informatics, the manager ensures adaptability in a fast-paced research environment. By combining scientific knowledge with strategic leadership, the senior manager drives innovation and operational excellence, playing a pivotal role in advancing the organization's mission to deliver transformative therapies to patients worldwide.The Senior Manager, Screening and Compound Management ensures the adherence to relevant regulatory requirements and company Standard Operating Procedures (SOPs) as appropriate..Job Description:ESSENTIAL FUNCTIONSPrimary duties/responsibilities:Lead the strategic planning and execution of high-throughput screening campaigns, ensuring that all activities align with organizational goals and project timelines.Leading cross-functional teams to design robust screening workflows, optimize assay conditions, and leading the implementation of cutting-edge technologies to enhance data quality and research throughput.Lead lab staff to Anticipate challenges, troubleshoot technical issues, and adapt strategies critical to maintaining the efficiency and reliability of screening operations.Provides detailed reports and analyses of screening outcomes, ensures that findings are effectively communicated to stakeholders and integrated into broader research initiatives.Oversees the management strategy of the compound library, a cornerstone of the organization's research and development efforts.Leads the Implementation of advanced inventory management systems and establishment and supervision of rigorous quality control protocols.Work closely with medicinal chemistry teams to expand the library with diverse and high-value compounds while maintaining compliance with regulatory and safety standards.Leads the team in the development of strategies to optimize compound storage conditions and ensure long-term stability, safeguarding the organization's investment in its chemical assets.Leads a multidisciplinary team of scientists and technicians, providing mentorship, performance feedback, and opportunities for professional growth.Leads continuous improvement initiatives to enhance the efficiency and impact of screening and compound management processes.Establishes key performance indicators (KPIs) to measure the effectiveness of processes and identify areas for optimization, ensuring that all initiatives are aligned with the organization's strategic objectives.KNOWLEDGE/SKILLS/ABILITIES REQUIRED* Minimum level of education and years of relevant work experience.Bachelor's degree in chemistry, biology, biochemistry, or a related field with a minimum of 8 years of experience in compound management, high-throughput screening, or a related area within the pharmaceutical or biotechnology industrySignificant relevant automation experience or Master's degree or Ph. D in a scientific related discipline is preferred.* Special knowledge or skills needed and/or licenses or certificates required.Hands-on experience in managing compound libraries, designing screening workflows, and utilizing automation technologies will be highly advantageous. For instance, experience in integrating robotic systems to streamline compound handling or implementing innovative screening technologies to improve efficiency will be considered a strong asset.Competency in at least one programming language is required. Examples C++, Visual Basic, Python, JavaScript, Java. Proficiency in laboratory automation systems, liquid handling platforms, and data management tools.Familiarity with software systems such as LIMS (Laboratory Information Management Systems) and cheminformatics platformsAbility to troubleshoot technical challenges in a dynamic research environment.*Special knowledge or skills and/or licenses or certificates preferred.The position also demands a strategic mindset and a commitment to driving continuous improvement. Candidates should be adept at identifying emerging trends in screening technologies and compound management, leveraging these insights to advance innovation within the organization.A proactive approach to problem-solving and a focus on operational excellence will be key to success.Balancing technical expertise with strategic vision will enable the Manager of Screening and Compound Management to make a significant impact on the organization's research and development efforts.* Travel requirementsLimited travel between PTC facilities in New Jersey
