CMC Manager
6 days ago
Retro develops therapies for diseases driven by the biology of aging. We focus on cellular reprogramming and autophagy to rejuvenate cell and tissue function with the ultimate aim of adding 10 years to healthy human lifespan.
We're building a mission-driven team of accomplished and kind individuals who embrace our startup culture of rapid iteration, transparency, and versatility.
Our autophagy program is advancing rapidly and leading the charge in translating our science into a first-in-human clinical trial, marking a major step toward delivering transformative therapies rooted in the biology of aging.
We're hiring a new team member on the Autophagy team who will coordinate and optimize the operational infrastructure needed to advance our autophagy-enhancing compounds toward the clinic. In this highly cross-functional role, you'll serve as a key link between Drug Discovery and Chemistry, Manufacturing, and Controls (CMC) to ensure a seamless transition from hit identification and lead optimization to preclinical candidate nomination. You'll drive small-molecule discovery efforts by managing medicinal chemistry activities at CRO partners and aligning cross-functional timelines to keep projects moving forward efficiently. This role reports to the Head of Chemistry and Early Drug Development.
About you:
You share our sense of urgency and excitement, and thrive in fast-paced, interdisciplinary environments. You work well independently but will also enjoy being part of a highly-collaborative, multi-disciplinary team. You are excited to take on tough challenges and contribute to advancing therapies that extend healthy human lifespan
In this role you will:- Managing CROs, CDMOs, and managing day-to-day execution and vendor relationships.
- Lead route scouting, process chemistry, analytical activities, and manufacturing of small-molecule investigational products.
- Contribute to the development and implementation of CMC strategies, and ensure compliance with regulatory requirements.
- Manage drug substances and internal chemical libraries with proper documentation and traceability.
- Working closely with internal teams such as clinical operations, regulatory, Sciops, and others to align on timelines and ensure seamless supply chain operations.
- Forecast drug supply needs, managing inventory, and supporting clinical supply activities, such as import and export, customs clearance, etc.
- This role includes at least some hands-on work, and is not a 100% desk job.
- A bachelor's degree with 10+ years of industry experience or PhD with 5+ years of industry experience in organic chemistry or related fields.
- Experience managing external CROs for research and development of small molecule drug substance and drug product.
- Basic understanding of regulatory documentation (Module 3 of the CTD, IND/IMPD content).
- Experience in forecasting and inventory management.
- Excellent communication, interpersonal, and problem-solving skills.
- Experience with clinical trial supply planning, including labeling and packaging, import/export coordination, and depot and site distribution.
- Knowledge in IND/IMPD/CTN submissions.
- Exposure to autophagy-related programs or aging biology.
At Retro, we don't use titles. New hires join as a "Member of X Team." Depending on experience, this role could flex from an Associate Manager to Manager level. Total compensation includes competitive base salary, generous equity, and benefits including:
- Medical, dental, and vision insurance for you and your family
- 401(k) plan with 4% matching
- Flexible time off and 10 company holidays per year
- Paid parental leave
- Annual learning & development stipend
- Daily Retro-sponsored lunch and snacks
We take pride in cultivating an environment that fosters collaboration, open communication, and authenticity. We believe that great results are best delivered by a highly creative team working in concert. We are an equal opportunity employer; we do not discriminate based on race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status. We are diverse in background and singular in mission.
We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.
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