Senior Protein Engineer Scientist

5 days ago


Seattle, United States Vertex Full time

Job DescriptionGeneral Summary:Our Seattle site is seeking a talented and motivated Protein Engineer (Senior Scientist) to join our dynamic team. If you are passionate about advancing scientific research and developing novel therapeutics, this role is for youKey Duties and Responsibilities:Design and execute protein engineering/directed evolution campaigns to improve binding affinity, stability, and selectivity.Utilize yeast surface display technology for library screening and directed evolution.Drawing from a deep array of Rosetta scripts and machine learning tools, create computational design strategies to deliver protein drug candidates.Effectively communicate design strategies to interdisciplinary team members.Collaborate with cross-functional teams to optimize protein candidates for function, manufacturability, and immunogenicity.Prepare reports, papers, and patent applications, collaborating closely with inventors, scientists, and legal counsel.Knowledge and Skills:Strong understanding of the biophysics of protein structure/function relationshipsProven experience in directed evolution, yeast surface display, and protein engineering.Demonstrated proficiency in protein modeling and design utilizing Rosetta software suite, Alphafold2, ColabFold, Protein MPNN, RFdiffusion or equivalent tools for insilico protein engineeringStrong analytical skills and attention to detailExcellent communication and teamwork abilitiesFamiliarity with antibody engineering and affinity maturationExperience in cellular assay developmentUnderstanding of cell biology and immunologyEducation and Experience:Ph.D. (or equivalent degree) in Computational Biology, Bioengineering, Chemical Engineering, or related field and 2-5 years of relevant post-doctoral, industry employment experience, orM.S. (or equivalent degree) in Computational Biology, Bioengineering, Chemical Engineering, or related field and 5+ years of relevant industry employment experience, orB.S. (or equivalent degree) in Computational Biology, Bioengineering, Chemical Engineering, or related field and 8+ years of relevant industry employment experienceThis position will be based out of our Seattle site location focused on protein engineering for the organization. Over the past 9 years we have utilized protein engineering to create a robust pipeline including Acazicolcept (ALPN-101) and Povetacicept (ALPN-303)



  • Seattle, United States Breakwater Therapeutics Full time

    Location: Seattle, WA (onsite) Company: Breakwater Therapeutics (stealth mode) About the Company We’re an early‑stage venture‑backed biotech operating in stealth mode, and we are focused on mAb‑based therapeutics. We’re building a nimble team that thrives in ambiguity, moves quickly from idea to experiment, and collaborates closely across science...


  • Seattle, United States Xaira Therapeutics Full time

    Xaira is an innovative biotech startup focused on leveraging AI to transform drug discovery and development. The company is leading the development of generative AI models to design protein and antibody therapeutics, enabling the creation of medicines against historically hard‑to‑drug molecular targets. It is also developing foundation models for biology...


  • Seattle, Washington, United States Monod Bio Full time $120,000 - $175,000 per year

    About UsMonod Bio is a pioneer company in the design of de novo protein biosensors. Our innovative biosensor platform technology takes advantage of the most recent advances in computational protein engineering to create highly modular biosensing nano-switches that enable rapid, sensitive, and inexpensive analytical assays. Our visionary founding team and...


  • Seattle, United States Xaira Therapeutics Full time

    Xaira is an innovative biotech startup focused on leveraging AI to transform drug discovery and development. The company is leading the development of generative AI models to design protein and antibody therapeutics, enabling the creation of medicines against historically hard-to-drug molecular targets. It is also developing foundation models for biology and...


  • Seattle, Washington, United States Monod Bio Full time

    About UsMonod Bio is a pioneer company in the design of de novo protein reagents for Life Sciences and Diagnostics. Our innovative design platform technology takes advantage of the most recent advances in deep learning computational protein engineering to create highly rapid and sensitive protein-based reagents and assays. Our visionary founding team and...


  • Seattle, United States Tech Digital Full time

    Scientist PositionPosition Summary: Cell Therapy Product and Analytical Development (P&AD) is seeking an enthusiastic, self-driven Scientist to join its Residual, Ancillary Materials and Protein Characterization analytical development team. The Scientist will lead development of analytical methods to characterize process-related impurities and assess...


  • Seattle, United States red violet (NASDAQ: RDVT) Full time

    Join to apply for the Data Scientist/Senior Data Scientist role at red violet (NASDAQ: RDVT) At red violet, we build proprietary technologies and apply analytical capabilities to deliver identity intelligence. Our technology powers critical solutions, which empower organizations to operate with confidence. Our solutions enable the real-time identification...


  • Seattle, United States Breakwater Therapeutics Full time

    Senior Principal Scientist / Associate Director / Director, Bioanalytical Bioanalytical (BioA) – Senior Principal Scientist / Associate Director / Director Location: Seattle, WA (onsite) Company: Venture-backed biotech (stealth mode) About the Company Breakwater Therapeutics is an early‑stage, venture‑backed biotech operating in stealth mode. We’re...


  • Seattle, Washington, United States Oracle Full time

    At Oracle Cloud Infrastructure (OCI), we build the future of the cloud for Enterprises as a diverse team of fellow creators and inventors. We act with the speed and attitude of a start-up, with the scale and customer-focus of the leading enterprise software company in the world. The Oracle Cloud Infrastructure (OCI) Generative AI science team is responsible...


  • Seattle, WA, United States Geosyntec Consultants Full time

    An environmental engineering consulting firm is hiring a Senior Staff Engineer or Scientist in Seattle, WA. The role involves applying expertise in environmental risk assessment, managing data, and preparing technical reports. The ideal candidate will have a Bachelor's in biology or toxicology, experience in environmental consulting, and strong communication...