Scientist 1 - Bioconjugation Chemistry
2 weeks ago
From research and discovery to post-market clinical development, our WWRD engine involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with genetic diseases.
Duties
- Synthesis, optimization, and high-quality delivery of various polymer, protein/peptide, and lipidated bioconjugates in support of discovery and development of novel therapeutics, with an emphasis on oligonucleotides
- Development and implementation of new linker chemistries/spacers and bioconjugation methods for targeted drug delivery
- Leveraging appropriate purification and analytical characterization approaches for QC and validation
- Collaboration with internal and external partners for material transfer to support in vitro and in vivo POC experiments; assemble data packages and maintain quality control documentation through Benchling for final product delivery.
- Effectively partner with cross-functional teams, sharing insights, troubleshooting issues, and driving science forward from the bench
- Serve independently as bioconjugation technical lead and subject matter expert for internal and external project communications
- Perform data analysis, interpret, and present results during internal and external meetings; attend and participate in scientific proceedings.
- Prepare and optimize chemistry SOPs
- Participate and present data and share responsibility for project milestones
- Extensive experience with different bioconjugation strategies and optimizations thereof for polymers, proteins/peptides, lipids, oligonucleotides and other biomolecules
- In-depth experience in bioconjugate purification techniques including various liquid chromatography methods (e.g. RP, IEX, SEC, HIC, affinity, FPLC) and membrane filtrations (e.g. TFF)
- Prior experience in biochemistry techniques and analytical methods such as SEC-MALs, LCMS, SPR/BLI, ELISA, SDS-PAGE, enzyme activity assays, etc.
- Willingness to learn new bioconjugation chemistries or delivery modalities and work across diverse therapeutic areas to develop protein therapeutics.
- Strong analytical mindset and chemistry problem-solving with creative thinking
- The position requires organization skills, attention to detail, self-motivation, and strong teamwork in a fast-paced setting
- Ph.D. in Chemical Engineering, Chemical Biology, Chemistry, or related fields is required; Scientist 1 will have 0-2 years of industry/post-doc experience relating to drug development
- Strong foundation in macromolecular chemistry, bioconjugation, analytical chemistry and/or chemical biology is strongly desired.
- A record of accomplishments/publications in relevant scientific discipline and some hands-on experience in oligonucleotide delivery is preferred but not required.
An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.
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