Research and Development Scientist

3 days ago


San Mateo, California, United States R&D Partners Full time

About the Role

R&D Partners is seeking a highly skilled Research and Development Scientist to join our team in San Carlos, CA.

This position involves contributing to process characterization efforts for our pneumococcal conjugate vaccine program, with the opportunity to work on conjugation process development for pipeline programs in the future.

The ideal candidate will have significant laboratory experience and a strong understanding of analytical chemistry principles.

Main Responsibilities

  • Optimize and troubleshoot multi-step syntheses of protein-polysaccharide conjugates.
  • Purify polysaccharides and conjugates using various methods, including dialysis, size-exclusion chromatography, and tangential flow filtration (TFF).
  • Analyze polysaccharides and conjugates using various analytical methods and develop new laboratory workflows as needed.
  • Advise team members on experimental design, result interpretation, and troubleshooting.
  • Model and train team members on best practices for protocol adherence and data management.
  • Serve as a subject matter expert during tech transfer of conjugation processes to contract manufacturing organizations.
  • Maintain organized records to enable optimization and reproducibility assessment.
  • Participate in team meetings to provide updates on conjugation development progress.

Requirements

  • PhD in chemistry, biochemistry, or a related field with 2-5+ years of industry experience.
  • Strong knowledge base in biochemistry and organic chemistry, with experience preparing bioconjugates.
  • Proficiency in small- and large-scale techniques for purification of bioconjugates, including TFF.
  • Proficiency in various techniques for bioconjugate analysis, such as colorimetric assays, HPLC, and SEC-MALS.
  • Sufficient knowledge of analytical principles to develop fit-for-purpose analytical methods and provide feedback on draft methods.
  • Experience with Design of Experiments is desirable.
  • Experience with chemical modification of polysaccharides is desirable.

Compensation

The estimated annual salary for this position is $152,000 - $170,000, depending on qualifications and experience.

About R&D Partners

R&D Partners is a global functional service provider and strategic staffing resource specializing in scientific, clinical research & engineering.

We provide job opportunities within major pharmaceutical, biopharmaceutical, biotechnology, and medical device companies.

R&D Partners is an equal-opportunity employer.


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