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Senior Research Investigator/Research Investigator, Quantitative Systems Pharmacology

2 months ago

Princeton, New Jersey, United States Pharmiweb Full time
Transforming Patients' Lives through Science

Bristol Myers Squibb is a leading pharmaceutical company dedicated to transforming patients' lives through science. We are seeking a highly motivated and experienced Research Investigator/Senior Research Investigator to join our Quantitative Systems Pharmacology and Pharmacometrics team.

Job Summary

The successful candidate will be responsible for developing and applying Quantitative Systems Pharmacology (QSP) models to address drug-discovery and development questions. This will involve working closely with biologists, clinicians, pharmacometricians, and other stakeholders to develop and rigorously assess the functionality, feasibility, efficiency, and validity of new models.

Key Responsibilities
  • Develop and apply QSP models to address drug-discovery and development questions
  • Collaborate with multidisciplinary project teams to develop and apply QSP models to aid in target prioritization, therapeutic modality selection, biomarker characterization, and early clinical trial design
  • Conduct extensive literature review to identify suitable mechanistic elements, interactions, rate constants, and sub-modules for incorporation into systems (disease) models
  • Partner with external groups to accelerate the internal Systems Pharmacology efforts in key disease areas
  • Contribute to the design, execution, and interpretation of clinical studies
  • Maintain an active relationship with colleagues in Clinical Pharmacology & Pharmacometrics as well as in the advancement of Pharmacometrics
  • Network with stakeholders in Discovery Biology, Clinical Development, and Translational Medicine to facilitate model development and application
  • Align QSP model deliverables with clinical pharmacology and clinical development plans
  • Coordinate with the QSP&PBPK methods lead on methodologies for virtual population workflows and script-based analysis packages and customize as needed
Requirements
  • Ph.D. in Engineering, Mathematics, Bioinformatics, Pharmacometrics, Systems Biology/Pharmacology, or a related field
  • 2+ years of mathematical modeling and computer simulation experience in the pharmaceutical industry for the Sr. Research Investigator level
  • Experience within the pharmaceutical industry or pharmaceutical consulting is desired (academic post-doctoral or faculty may be a consideration depending on the totality of prior experience)
  • Excellent oral and written communication skills and the ability to interact effectively with scientists in other disciplines with a positive, collegial, and collaborative attitude
  • Excellent understanding of theory, principles, and statistical aspects of advanced mathematical modeling and simulation, including numerical methods, parameter estimation/optimization, ordinary differential equations (ODEs), and how these can be applied in the development of complex models of biological pathways/systems
  • Good understanding of the basic principles of pharmacokinetics and pharmacodynamics
  • Ability to learn new areas of biological sciences and build on solid foundation of quantitative skills to develop QSP models
  • Ability to keep up to date with and propose the implementation of scientific and technological developments in the area of Systems Pharmacology/Biology
  • Hands-on experience with modeling software like MATLAB/SimBiology is required
  • Experience with general programming and data analysis tools/languages such as Python, R, Spotfire would be particularly desirable
What We Offer

Bristol Myers Squibb offers a competitive compensation package, including a range of benefits, services, and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. We are committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments, and ongoing support in their roles.

We are an equal opportunities employer and welcome applications from diverse candidates. If you are passionate about transforming patients' lives through science, we encourage you to apply for this exciting opportunity.