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Senior Quantitative Systems Pharmacology Investigator/Quantitative Systems Pharmacology Investigator, Bristol Myers Squibb
2 months ago
Bristol Myers Squibb is seeking a highly motivated scientist to join our Quantitative Systems Pharmacology (QSP) team in Cambridge, MA. As a Senior Quantitative Systems Pharmacology Investigator or Quantitative Systems Pharmacology Investigator, you will play a critical role in developing and applying QSP models to address drug-discovery and development questions.
Key Responsibilities- Develop and apply QSP models to address drug-discovery and development questions.
- Function as part of a team to develop and rigorously assess the functionality, feasibility, efficiency, and validity of new models.
- Conduct extensive literature reviews to identify suitable mechanistic elements, interactions, rate constants, and sub-modules for incorporation into systems (disease) models.
- Provide leadership to and collaborate with multidisciplinary project teams to develop and apply QSP models to aid in target prioritization, therapeutic modality selection, biomarker characterization, and early clinical trial design.
- Partner with external groups to accelerate the internal Systems Pharmacology efforts in key disease areas.
- Contribute to the design, execution, and interpretation of clinical studies.
- Maintain an active relationship with colleagues in Clinical Pharmacology & Pharmacometrics as well as in the advancement of Pharmacometrics.
- Network with stakeholders in Discovery Biology, Clinical Development, and Translational Medicine to facilitate model development and application.
- Align QSP model deliverables with the clinical pharmacology and clinical development plans.
- Coordinate with the QSP&PBPK methods lead on methodologies for virtual population workflows and script-based analysis packages and customize as needed.
- Stay informed with emerging literature and science in the systems biology/pharmacology modeling and simulation sciences.
- Build and maintain a personal track record of publication in the area of QSP.
- Ph.D. in Engineering, Mathematics, Bioinformatics, Pharmacometrics, Systems Biology/Pharmacology, or a related field.
- 2+ years of mathematical modeling & computer simulation experience in the pharmaceutical industry for the Senior Quantitative Systems Pharmacology Investigator level. No additional industry experience is needed for the Quantitative Systems Pharmacology Investigator level.
- Experience within the pharmaceutical industry or pharmaceutical consulting is desired (academic post-doctoral or faculty may be a consideration depending on the totality of prior experience).
- Excellent oral and written communication skills and the ability to interact effectively with scientists in other disciplines with a positive, collegial, and collaborative attitude.
- Excellent understanding of theory, principles, and statistical aspects of advanced mathematical modeling and simulation, including numerical methods, parameter estimation/optimization, ordinary differential equations (ODEs), and how these can be applied in the development of complex models of biological pathways/systems.
- Good understanding of the basic principles of pharmacokinetics and pharmacodynamics.
- Ability to learn new areas of biological sciences and build on a solid foundation of quantitative skills to develop QSP models.
- Ability to keep up to date with and propose the implementation of scientific and technological developments in the area of Systems Pharmacology/Biology.
- Hands-on experience with modeling software like MATLAB/SimBiology is required.
- Experience with general programming and data analysis tools/languages such as Python, R, Spotfire would be particularly desirable.
- Desire to interact as a modeling and simulation expert across clinical development teams with experts from different functional areas (pre-clinical and clinical).
- Familiarity with the challenges and general application of mathematical modeling/simulation in pharmaceutical R&D.
The starting compensation for this job is a range from $97,000 - $135,000, plus incentive cash and stock opportunities (based on eligibility). Final, individual compensation will be decided based on demonstrated experience. Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit our BMS Career Site. Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental, and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection, and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder, and pet care resources. Other perks like tuition reimbursement and a recognition program.
About Bristol Myers SquibbBristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.
