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Senior/Executive Director, Clinical Pharmacology and Therapeutic Innovation

2 months ago

Conshohocken, Pennsylvania, United States Madrigal Pharmaceuticals Corporation Full time
Job Description

Madrigal Pharmaceuticals Corporation is seeking a highly skilled and motivated Clinical Pharmacologist to join our dynamic research and development team. The ideal candidate will have extensive experience in the application of pharmacokinetic (PK) and pharmacodynamic (PD) principles to drug development, with a focus on modeling and simulation to predict drug behavior, optimize dosing, and improve therapeutic outcomes.

Key Responsibilities:
  • Design and Conduct Pharmacokinetic Studies: Develop and execute pharmacokinetic studies, including both preclinical and clinical trials, to support drug development and regulatory submissions.
  • Apply Pharmacokinetic/Pharmacodynamic Modeling and Simulation: Utilize PK/PD models and simulation techniques to support drug development, dose optimization, and regulatory submissions.
  • Collaborate with Cross-Functional Teams: Work with research scientists, clinical researchers, and regulatory affairs to integrate PK/PD analyses into overall drug development strategies.
  • Communicate PK/PD Findings: Interpret and communicate PK/PD modeling and simulation findings to non-specialist stakeholders, including project teams and regulatory agencies.
  • Stay Current with Industry Developments: Stay abreast of the latest developments in pharmacokinetics, pharmacodynamics, and modeling and simulation methodologies.
  • Contribute to Regulatory Submissions: Contribute to the preparation of regulatory submissions, scientific publications, and presentations at scientific conferences.
Requirements and Qualifications:
  • PhD in Clinical Pharmacology or Related Field: PhD in Clinical Pharmacology or a related field, with a strong focus on pharmacokinetic modeling and simulation.
  • Experience in Drug Development: Minimum of 5 years of experience in a drug development setting, with a proven track record of applying PK/PD modeling and simulation in the pharmaceutical industry.
  • Software Skills: Experience with software tools for pharmacokinetic modeling and simulation (e.g., NONMEM, Phoenix WinNonlin, MATLAB, R).
  • Regulatory Knowledge: Understanding of the drug development process, including regulatory requirements related to pharmacokinetics and pharmacodynamics.
  • Expertise in Pharmacokinetics: Demonstrated expertise in developing and executing drug distribution, metabolism, and pharmacokinetics studies.
  • Analytical and Problem-Solving Skills: Excellent analytical and problem-solving skills, with the ability to interpret complex data and translate findings into actionable drug development strategies.
  • Communication and Collaboration Skills: Effective communication and collaboration skills, with the ability to work as part of a multidisciplinary team and interact with a wide range of stakeholders.
  • Publication Record: Publication record demonstrating contributions to the field of pharmacokinetics and pharmacodynamics.
Compensation and Benefits:

Madrigal Pharmaceuticals Corporation offers a competitive compensation package, including a base salary, bonus, equity, and comprehensive benefits, which include flexible paid time off (PTO), medical, dental, vision, and life and disability insurance.

Madrigal Pharmaceuticals Corporation is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex, gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law.