Senior Research Scientist

4 hours ago


Memphis, Tennessee, United States St. Jude Children's Research Hospital Full time
Job Title: Lead Researcher/Scientist

We are seeking highly motivated and creative candidates for a Scientist or Lead Researcher role in Dr. Jonathan Yen's lab and a new Therapeutic Genome Engineering (TGEn) group. Our team is part of a multidisciplinary team of scientists and clinical researchers working to advance genome editing strategies to treat sickle cell disease.

Job Responsibilities:
  • Develop genome editing strategies for human hematopoietic stem cells.
  • Design and execute IND-enabling experiments to characterize the pharmacology of a genome-edited human hematopoietic stem cell product.
  • Characterize the efficacy and potency of the cellular drug product in in vitro and xenotransplantation assays.
  • Collaborate with multidisciplinary teams to advance the program.
  • Evaluate scale-up and close-system processes to ensure the reproducibility of the drug products.
  • Conduct exploratory research on developing novel in-vitro and in-vivo delivery strategies.
  • Establish tracking and trending analyses of process development and pilot runs.
  • Draft documentation (protocols, batch records, reports) to standardize and transfer process to GMP facility.
Requirements:
  • Bachelor's degree in a relevant scientific area.
  • Five (5) years of relevant post-degree work experience for Lead Researcher role.
  • Seven (7) years of relevant post-degree work experience for Scientist role.
Compensation:

A reasonable estimate of the current salary range is $65,520 - $114,400 per year for the role of Lead Researcher or Scientist - Jonathan Yen Lab (Therapeutic Genome Engineering).

Diversity, Equity and Inclusion:

St. Jude Children's Research Hospital values diversity, equity and inclusion and is committed to creating a workplace that is equitable and culturally responsive.



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