Biomedical Researcher, Liver Disease Therapies

7 days ago

Étreux, Hauts-de-France, United States Takeda Pharmaceutical Company Ltd Full time
Research Scientist Opportunity

We are seeking a highly skilled Research Scientist to join our team at Takeda Pharmaceutical Company Ltd. in Boston, MA.

About the Role

This position is part of our Liver Disease Research group, focused on validating novel targets and evaluating drug candidates for chronic fibroinflammatory liver diseases.

As a Research Scientist, you will apply expertise in executing in vitro studies relevant to fibroinflammatory liver disease biology and pharmacology.

You will play a central role in generating key data for evaluating potential targets, mechanism of action and/or drug candidate efficacy and pharmacodynamics.

  • You will design and execute relevant target and drug candidate validation studies using contemporary methods and tools.
  • You will determine mechanism of action for drug targets and candidates with appropriate controls.
  • You will implement target-specific assays to assess target and drug activity in vitro and/or in vivo, as appropriate.
  • You will identify orthogonal applications of target, pathway, or platform biology in other fibroinflammatory diseases.
  • You will participate on cross-functional teams and provide technical leadership in area of expertise.
  • You will prepare technical reports, summaries, protocols, and quantitative analyses in written and/or oral form.
  • You will proactively identify complex obstacles to progress in specific areas and recommend solutions.
Requirements and Qualifications

To be successful in this role, you will need:

  • A PhD degree in a scientific discipline (or equivalent), or MS with 6+ years relevant experience, or BS with 8+ years relevant experience in vitro drug discovery research.
  • Demonstrated ability to independently solve scientific problems using multiple, state-of-the-art technologies and approaches.
  • Significant experience with drug discovery applications of cell culture including immortalized cell lines, primary cell cultures, and multicellular or organoid culture models, preferably models that recapitulate cellular cross-talk in fibroinflammatory or diseased tissues.
  • Expertise in at least one of the following assay methods: ELISA, Western blot, qPCR, flow cytometry, ChIP.
  • Experience and continued willingness to work with live rodents and animal tissue.
  • Demonstrates exceptional project management skills and in-depth in vitro cell and molecular biology assay experience.
Compensation and Benefits

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.

The estimated salary range for this position is $108,500 - $170,500 per year, based on qualifications and experience. In addition to base salary, U.S. based employees may be eligible for short-term and/or long-term incentives, medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits.

Equal Employment Opportunity

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws.

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