Principal Scientist
2 days ago
We are seeking a highly motivated Principal Scientist to join our Mammalian Expression Technologies Center of Excellence (MET CoE) at GSK Vaccines. As a key member of our team, you will play a critical role in shaping our next-generation cell line engineering initiatives.
Located in Cambridge, MA, this position offers a unique opportunity to integrate with a diverse group of top experts in the vaccines industry, lead key activities, and further grow and progress in your career.
Key Responsibilities- Design and develop omics-based screening strategies for the discovery of novel gene targets in CHO cells.
- Perform advanced NGS data analytics to elucidate key biological targets for next-generation CHO host evolution.
- Stay up-to-date with the latest quality and regulatory guidance to support project documentation and accelerated CMC timelines.
We are looking for professionals with the following required skills:
- PhD with 2+ years of industry experience in molecular biology, computational biology, genetics, or another relevant field.
- Two or more years of experience with NGS techniques (wet and dry lab) and associated methodologies, including analyses of large datasets.
- Two or more years of experience with the implementation of genome-scale modeling approaches to establish biological and mechanistic networks.
The following skills are a plus for this role:
- Hands-on experience with mammalian cell culture, including clonal derivation and transfection.
- Experience with genome-editing tools for mammalian cell engineering.
- Deep understanding in CMC drug substance space as it relates to cell line development.
Why GSK?
GSK is a global biopharma company with a special purpose - to unite science, technology, and talent to get ahead of disease together. We prevent and treat disease with vaccines, specialty, and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/immunology, and oncology).
We are committed to creating a workplace where people feel inspired, encouraged, and challenged to be the best they can be. A place where they can be themselves - feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing.
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