Principal Oligonucleotide Data Scientist
2 days ago
GSK is at the forefront of oligonucleotide research, and we're seeking a talented Principal Oligo Data Scientist to join our team. As a key member of our Oligo Sciences team, you'll play a crucial role in designing and developing innovative oligonucleotide therapies.
Key Responsibilities:- Develop a target/complex engagement model that integrates target sequence, secondary+ tertiary structure, and oligo chemistry to drive binding assay designs for high-throughput screening and low-latency optimization.
- Support the design and implementation of a target tractability system for oligo-guided therapeutic mechanisms such as RNA degradation/interference, and up/down modulation of alternative splicing, poly-adenylation, A>I editing, etc.
- Collaborate with renowned GSK experts in genetics, genomics, computational bio & chem, structural biology, and medicinal chemistry to build the datasets, tools, models, and infrastructure necessary for oligo design & development.
- MS degree in computational life science (bio/med/chem/stats/informatics) with at least 1 published work and 5+ years of industry experience
- PhD degree in computational life science (bio/med/chem/stats/informatics) with at least 1 published work and 2+ years industry, post doc, or internship experience.
- 1+ year experience with Cheminformatic or structural modelling of drug-target binding for small or large molecules validated by real qSAR assays
- 1+ year experience with genomic data infrastructure for either public or private collections (e.g. ENCODE, TCGA, DepMap, GTEx, cellXgene, UK biobank)
- Performed target identification or tractability/prioritization for RNA-modulating approaches or RNA-targeted modalities
- Demonstrated cross-functional communication, matrixed collaboration, both team and thought leadership
GSK is a global biopharma company with a special purpose - to unite science, technology, and talent to get ahead of disease together. We prevent and treat disease with vaccines, specialty, and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/immunology, and oncology).
We want GSK to be a place where people feel inspired, encouraged, and challenged to be the best they can be. A place where they can be themselves - feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.
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, MA, United States GSK Full timeLead the Way in Oligonucleotide Analytical ChemistryWe are seeking a highly skilled and experienced Team Leader to lead our Oligonucleotide Analytical Chemistry team. As a key member of our team, you will be responsible for establishing and leading the oligonucleotide analytical team, collaborating cross-functionally to advance our pre-clinical portfolio and...
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