Senior Scientist

3 weeks ago


Boston, Massachusetts, United States Hillstar Bio Full time
Company Overview: Hillstar Bio is a leading precision immunology company focused on developing innovative treatments for autoimmune diseases. Our mission is to improve the lives of patients by advancing cutting-edge research and technologies.

Job Summary: We are seeking an experienced Principal Scientist/Associate Director Immunology to join our team and lead our preclinical immunology program, HLST-002. This role will involve designing and overseeing the execution of in vitro and in vivo mechanistic, efficacy, and safety studies. The ideal candidate will have a strong background in adaptive immune cell biology and experience in strategic thinking.

Key Responsibilities:
  • Design and execute in vitro and in vivo experiments to investigate disease-causing mechanisms and generate proof-of-concept studies.
  • Research and identify high-quality in vitro and in vivo models of autoimmune diseases; work with the VP of Immunology to create the overall preclinical strategy for HLST-002 and support the design of subsequent PK, tox, dosing studies.
  • Collaborate with scientists and RAs on detailed experimental plans and processes, including identification of appropriate controls, assay optimization, reagent selection, etc. for standard immunology and cell bio techniques (ELISA, flow cytometry, immunofluorescence, cell sorting, Western blotting, etc.).
  • Identify high-quality external CRO, vendor, and academic collaborators, and determine how they fit into a broader scientific workplan for HLST-002; work with external collaborators on detailed experimental design and interpretation of results.
  • Present findings and project updates to internal research and executive teams.
  • Assist in authoring technical reports for IP and regulatory filings.
  • Contribute to the growth and leadership of the immunology team.

Requirements: To be successful in this role, you will need:
  • A PhD in Immunology or related field.
  • A minimum of 5 years of experience in drug development in biotech or pharma setting, with research experience in autoimmune diseases.
  • Prior experience with adaptive (B and/or T cell)-mediated autoimmune diseases, experience seeing these programs through non-clinical into early clinical studies is highly preferred.
  • Prior experience advancing a program from early stage of conceptualization through in vitro and in vivo preclinical studies in a biotech or pharma context.
  • Prior experience managing junior lab-based scientists (e.g., RA, Scientist, Sr Scientist) and CRO/academic collaborations.
  • Relevant experience is reflected by a track record of patents and high impact publications.
  • Demonstrated excellence as a team player as evidenced by positive reviews from reports, peers, and managers.
  • Self-motivated, collaborative, excellent time management and interpersonal skills.
  • Demonstrated ability to communicate scientific workplans, strategy, and findings through presentations and slides.

Compensation and Benefits: Hillstar Bio offers a competitive compensation and benefits package that includes unlimited vacation and market-leading parental leave. Estimated salary range: $180,000 - $220,000 per year.
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