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Senior Scientist

2 months ago


Bedford, Massachusetts, United States PharmaEssentia U.S.A. Full time
Job Opportunity

PharmaEssentia U.S.A. is seeking a highly skilled and motivated Antibody Discovery and Engineering Scientist to join our Biologics Platform team.

About the Role

This is a highly scientific position that requires in-depth knowledge and expertise in molecular biology and yeast display technology. The successful candidate will be responsible for biologics lead discovery and engineering using the display library approach.

Key Responsibilities
  • Design and Build Display Libraries: Collaborate with structural and computational biologists to design and build naïve, immunized, and synthetic application-specific display libraries for antibody, cytokine, and TCR-based protein biotherapeutics.
  • Lead Discovery and Optimization: Conduct selection campaigns to identify lead molecules against various targets, and evaluate scientific strategies to ensure successful delivery of yeast display discovery campaigns.
  • Technical Expertise: Provide technical expertise and advice to team members, fostering an environment of continuous learning and growth.
  • Technology Implementation: Continuously assess and implement new technologies into the existing workflow to inspire creativity and contribute to an innovative product portfolio with diverse modalities.
Qualifications
  • PhD in Molecular Biology or Related Field: PhD in molecular biology, biological engineering, or related biological science disciplines with 2+ years of industrial experience in Biologics discovery function.
  • Yeast Display Technology Expertise: Strong hands-on experience with yeast display technology and antibody lead discovery and optimization including affinity, potency, and developability enhancement.
  • Molecular Biology and Flow Cytometry Skills: Proficiency in molecular biology (e.g., molecular cloning) and flow cytometry skills, including multi-parameter analysis and sorting.
  • Antibody Structure and Function: Strong understanding of antibody structure, function, and engineering.
Preferred Qualifications
  • Single B Cell Antibody Technology: Experience in single B cell antibody technology is highly preferred.
  • NGS Antibody Library Output Analysis: Proficient in NGS antibody library output analysis.
  • Protein Design and Modeling: Protein design and modeling experience using RoseTTAFold, AlphaFold, or equivalent.

At PharmaEssentia U.S.A., our goal is to develop innovative biotherapeutics that improve patient outcomes. We are committed to advancing transformative therapies in Oncology, Hematology, and Immunology disease areas. By joining our team, you will have the opportunity to contribute to cutting-edge research and development, and work with a talented team of scientists and engineers.