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Medicinal Chemistry Leader
2 months ago
Otsuka Pharmaceutical Company is a global healthcare leader with a commitment to delivering innovative products that improve human health worldwide.
The Director of Medicinal Chemistry will be a results-driven scientist with extensive experience in medicinal chemistry and a strong interest in the drug discovery process. This role will oversee the efficient design, synthesis, and characterization of important target drug compounds with suitable drug-like properties for biological testing.
Key Responsibilities:
- Provide scientific leadership in operating chemistry-related drug discovery projects.
- Implement and execute medicinal chemistry strategies with a blend of internal and external resources to deliver high-quality preclinical candidates.
- Drive innovative drug discovery strategies utilizing deep expertise across medicinal chemistry and synthetic chemistry route design.
- Lead drug discovery programs in effective collaboration with internal and external teams, including CROs.
- Utilize cutting-edge synthetic methodologies and techniques to design syntheses of target compounds within existing and novel chemical series.
- Interpret biological and ADME/PK data and design novel compounds that meet desired target profiles.
- Collaborate with academic/external partners and stay current with the competitive landscape.
- Manage interactions with cross-functional team leaders and project managers to support project progression to IND-enabling studies.
- Develop, implement, and deliver on team collaborations, including initial proposal development, planning timelines and resources, monitoring milestones and final deliverables.
- Responsible for monitoring, measuring, and reporting on scientific issues, opportunities, and developmental plans and achievements within agreed formats and timescales.
- Lead the preparation of project-specific patent documents as needed.
- Provide mentorship, guidance, and support to direct reports in their professional development.
- Collaborate with internal stakeholders, including project management, intellectual property, and regulatory teams, as well as BD, MSRD on activities related to early-phase target and asset identification to achieve project goals.
- Effectively communicate scientific findings, progress updates, and project strategies to senior management and external stakeholders.
- Provide expert advice to internal and external stakeholders and interact with subject matter experts for early development and go/no-go decisions.
- Provide expert advice to internal and external discovery teams as well as academic and early investment partners on incorporation of CMC techniques and studies in early development, lead optimization, and go/no-go decisions.
Requirements:
- PhD in medicinal chemistry and/or organic chemistry (or a related area) with a minimum 7-10 years of cutting-edge industry Early Discovery Research experience in a pharmaceutical and/or biotechnology environment.
- Experience in a leadership or managerial role and a strong scientific track record as evidenced by a strong track record of scientific publications, patents, and delivery of clinical product candidates.
- In-depth experience in a leadership or managerial role and a strong scientific track record as evidenced by a strong track record of scientific publications, patents, and delivery of clinical FIH product candidates.
- In-depth knowledge of medicinal chemistry, pharmacology, ADME, and pharmacokinetics related to CNS-based therapeutic targets/indications.
- Excellent knowledge of the latest developments in medicinal chemistry, CMC techniques, and IND-enabling studies leading drug candidates for First in Human (FIH) clinical testing.
- Ability to apply scientific knowledge (in the areas specified above) to further the company's products, anticipate and identify core problems, apply insightful analysis, and solve problems effectively.
- Excellent working knowledge of small molecule active (pharmaceutical) ingredient discovery technologies and processes.
- Experience in drafting patent applications and evaluating third-party patent applications.
- Ability to work to deadlines in a rapidly changing, fast-paced environment.
- Proven ability to build effective relationships with colleagues and external partners.
- Ability to think on both strategic and tactical levels, set goals, plan, and execute.
- Bias for action; a creative and detail-oriented approach to problem-solving and delivery.
- Exceptional cross-functional leadership and communication skills as well as experience in leading drug discovery in neurological disorders.
