Senior Scientist with Advanced Spatial Proteomics Expertise
2 weeks ago
We are seeking a highly motivated individual with a passion for cutting-edge technology to explore single cell multiplex spatial proteomics. This role involves working with the latest generation PhenoCycler Fusion instrument and collaborating with translational immunologists, cancer biologists, and other researchers to advance our understanding of cellular processes in complex tissues and their application to drug development.
About the Role:This role offers exciting opportunities for career development, enhancing leadership skills, and influencing collaborative efforts within various disease areas. The successful candidate will be responsible for operating, maintaining, and utilizing the PhenoCycler Fusion instrument, building and optimizing antibody panels, conjugating and performing quality control of reagents, and consulting with users on potential projects.
Key Responsibilities:- Operate, maintain, and utilize the PhenoCycler Fusion instrument.
- Build and optimize antibody panels.
- Conjugate and perform quality control of reagents.
- Consult with users on potential projects, including sample accessibility and experimental design.
- Optimize procedures, design panels, and provide data analysis consultation.
- Conduct multiplex imaging experiments.
- Perform basic data quality evaluation.
- Analyze data using licensed software.
- Maintain records of procedures and resultant data, both manually and on the computer.
- Serve as a leader in spatial proteomic single cell biology and translational research applications, focusing on new targets, biomarkers/patient population selection, and treatment strategies.
- Focus efforts in priority application areas in Biomedical Research (BR) at Novartis to deliver impactful results through matrix collaboration with DA teams.
- Building on success from initial focused efforts, develop broader application strategies at BR in translational and reverse translation research, with support from leaders in Discovery Science, Disease Areas, and Biomedical Research.
- Strong interpersonal and communication skills for close collaboration with team members.
- Ability to work effectively in a fast-paced, diverse environment.
- Good judgment, technical problem-solving, and analytical skills.
- Flexibility and adaptability as technology evolves.
- Prior experience in imaging techniques and applications in biological research.
- General lab skills and knowledge of lab safety and infection control.
- Ph.D. in immunology, biological sciences, biochemistry, or a related field, and 2+ years of related postgraduate work experience.
- Other technical and academic degrees will be considered with relevant research experience.
- 3+ years of demonstrated skill and experience using CODEX/PhenoCycler.
- Possess deep knowledge and expertise in immunology, biology, and multi-omics applications in translational research across various disease areas such as oncology (ONC), immuno-oncology (IO), immunity-driven diseases, and related treatment strategies.
- Understanding sample preparation, instrument optimization, and data analysis.
- Interest in bioinformatics and experience with software.
- Ability to identify and troubleshoot critical issues.
- Detail-orientated.
Our purpose is to reimagine medicine to improve and extend people's lives, and our vision is to become the most valued and trusted medicines company in the world. We are committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.
The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion, or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status.
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Cambridge, Massachusetts, United States Novartis Group Companies Full timeJob Description SummaryWe are seeking a highly motivated and experienced individual to join our team as a Principal Scientist with expertise in PhenoCycler Fusion technology. This role involves working with cutting-edge technology to explore single cell multiplex spatial proteomics and collaborating with translational immunologists, cancer biologists, and...
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Cambridge, Massachusetts, United States Novartis Group Companies Full timeJob Description SummaryWe are seeking a highly motivated and experienced individual to join our team as a Principal Scientist with PhenoCycler Fusion experience. This role involves working with the latest generation PhenoCycler Fusion instrument and collaborating with translational immunologists, cancer biologists, and other researchers to advance our...
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Cambridge, Massachusetts, United States Novartis Group Companies Full timeJob Description SummaryWe are seeking a highly motivated individual passionate about cutting-edge technology to explore single cell multiplex spatial proteomics. This role involves working with the latest generation PhenoCycler Fusion instrument and collaborating with translational immunologists, cancer biologists, and other researchers to advance our...
-
Cambridge, Massachusetts, United States Novartis Group Companies Full timeAbout the RoleWe are seeking a highly motivated individual passionate about cutting-edge technology to explore single cell multiplex spatial proteomics. This role involves working with the latest generation PhenoCycler Fusion instrument and collaborating with translational immunologists, cancer biologists, and other researchers to advance our understanding...
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Cambridge, Massachusetts, United States Novartis Group Companies Full timeAbout the RoleWe are seeking a highly motivated individual passionate about cutting-edge technology to explore single cell multiplex spatial proteomics. This role involves working with the latest generation PhenoCycler Fusion instrument and collaborating with translational immunologists, cancer biologists, and other researchers to advance our understanding...
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Cambridge, Massachusetts, United States Novartis Group Companies Full timeJob Description SummaryWe are seeking a highly motivated and experienced individual to join our team as a Principal Scientist with expertise in advanced spatial proteomics. This role involves working with cutting-edge technology, collaborating with translational immunologists, cancer biologists, and other researchers to advance our understanding of cellular...
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