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Rockville, Maryland, United States Arcellx, Inc. Full timeWho We AreArcellx is a clinical-stage biotechnology company reimagining cell therapy by developing innovative immunotherapies for patients with cancer and other incurable diseases. Our mission is to destroy cancer and advance humanity by creating cell therapies that are safer, more effective, and more accessible. Our team consists of talented innovators and...
Senior Translational Scientist, Biotechnology
2 months ago
We are seeking a highly skilled and experienced Senior Translational Scientist to join our Translational Sciences team at Arcellx. As a key member of our team, you will be responsible for driving the development and execution of translational strategy as projects move from discovery to early clinical development.
Key Responsibilities- Lead the implementation of clinical biomarker strategy to enable target engagement characterization, PK/PD indication of biologic activity and assessment of patient response.
- Contribute to the integration, influence, and execution of translational/biomarker plans.
- Communicate translational updates and conduct strategic discussions for key programs with diverse audiences, including senior management.
- Understand key cancer pathway interactions and feedback mechanisms in clinical samples to inform ongoing clinical trials.
- Define novel mechanisms of resistance by studying samples at relapse.
- Contribute relevant scientific expertise, strategy, and experimentally-derived insights as a member of multidisciplinary project teams working to drive the preclinical to clinical translation of pipeline assets.
- Plan, design, and execute IND-enabling pharmacology, pharmacokinetic and toxicology studies by applying knowledge of disease-associated pathways, preclinical models, and drug development.
- Contribute to the preparation of IND applications and other regulatory documents, as appropriate, leveraging up-to-date knowledge of FDA cellular therapy guidance.
- Establish and cultivate relationships with external CRO collaborators for basic and translational research.
- Maintain a current and comprehensive understanding of disease biology, treatment paradigm, and competitive landscape for key programs.
- PhD, MD or MD/PhD degree in a relevant scientific field (e.g., cancer biology, immunology, hematology) with 3+ years of experience in a formalized Translational Science/Medicine role within a large pharma/biotech company is required.
- Understanding of early or late-stage drug and translational development process, including clinical trial experience in industry or academia.
- In-depth understanding of myeloid disease biology (e.g., AML, MDS), knowledge of clinical landscape, evolving therapy, and competitive scenarios.
- Demonstrated record of research accomplishment as evidenced by publications or major contributions to drug development milestones.
- Highly developed problem solving and risk management abilities.
- Strategic thinker with proven leadership skills and/or prior project team leadership roles.
- Proficiency in distilling complex issues and clearly articulating viable paths forward.
We offer a competitive compensation package, including an annual bonus based on company goals and an equity (RSU) grant. Our market-leading benefits package includes: 100% coverage for medical, dental and vision for team members and dependents, unlimited vacation, a 3-day weekend every month, fully-paid parental leave for up to 6 months, tuition reimbursement, 401k employer contribution and more.
