DMPK Director

2 weeks ago


San Diego, California, United States Recludix Pharma Inc Full time
Job Title: DMPK Director

Recludix Pharma Inc is seeking an experienced DMPK Director to lead our small molecule drug discovery and development efforts in inflammation and oncology. The successful candidate will have strategic and scientific oversight of our small molecule portfolio and will manage the in vitro and in vivo PK, ADME and bioanalytical assays.

Responsibilities:
  • Design, plan, execute, interpret and report scientific experiments for DMPK activities.
  • Provide leadership and strategic direction for DMPK in inflammatory/autoimmune disease and oncology programs.
  • Contribute to and influence the DMPK components in the screening funnel and criteria for compound selection and advancement of research programs into development.
  • Implement/manage quantitative bioanalysis of plasma and other biological matrices to support pharmacokinetic, toxicokinetics, and in vitro ADME analyses of novel small molecule therapeutics.
  • Conduct PK and PK/PD modeling using non-compartmental and compartmental models.
  • Responsible for reviewing BA and TK reports from nGLP and GLP tox studies.
  • Organize and maintain data.
  • Present data at project team meetings.
  • Guarantee the prompt completion and review of high-quality DMPK reports.
  • Contribute to nonclinical PK/ADME sections in regulatory documents (e.g., IB, IND, etc...).
  • Actively participate on program teams as a key representative of nonclinical sciences.
Requirements:
  • PhD and 8+ years of industry experience in DMPK supporting programs transitioning into development.
  • Expertise in monitoring, managing and translating studies across discovery and development.
  • Experience with small molecule drug development, including modelling of dose projections.
  • Strong scientific leadership, creativity, problem-solving abilities and a track record of managing external partners.
  • Experience with development of Immunology therapeutics highly desirable.
  • Excellent communication, presentation, writing, coaching skills.

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