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Research Scientist I
2 months ago
We are seeking a highly motivated Research Scientist I to join our team at Frontage Laboratories Inc. Our core competencies include drug metabolism, pharmacokinetics/pharmacodynamics (PK/PD), safety and toxicology, bioanalytical services, chemistry and manufacturing controls for drug development, and core laboratory services for clinical trials.
The successful candidate will develop and conduct biochemical and cellular assays used to evaluate potential therapeutics. Assay requests range from implementing kits to developing assays from scratch following literature review. Methodologies include ELISA, MSD, Flow Cytometry, transient and stable cell-line transfection, RNA extraction, qPCR, Western Blot, and luminescent, colorimetric, and fluorescent plate-based assays. We also employ robotic automation to enable high throughput screening.
This position works with an interdisciplinary team of DMPK scientists, pharmacologists, and analytical chemists. It is lab-based, collaborative, and client-facing. While delivering accurate, scientifically sound results is our priority, we pride ourselves in being exceptionally responsive and flexible for our clients, using creativity to meet their early-phase drug discovery goals.
Key Responsibilities:
- Plan and run defined protocols for various 96-well and 384-well plate-based assays daily.
- Analyze results using in-house and client-developed templates.
- Identify and troubleshoot errors and assess validity of unexpected results.
- Help develop and establish new assays to address individual clients' needs.
- Maintain and use cells in culture.
- Assist with preparing informal and formal protocols and reports.
- Discuss with colleagues and clients about experimental design and results.
- Maintain a lab notebook.
- Other duties, as assigned.
Requirements:
- PhD in cell biology, biochemistry, or related field with extensive academic and/or industry lab experience required.
- Industry-based lab experience not required for Entry Level candidates.
- Experience with ELISA, cell culture, cellular assays, and gene expression.
- Prior experience developing assays with colorimetric, luminescence, and fluorescence readouts as well as multi-color flow cytometry.
- Previous experience in a discovery project is highly desired.
- Understanding of drug discovery processes would be helpful.
- Excellent organization, planning, and communication skills.
- Critical attributes: attention to detail, self-motivated, willingness to ask questions.
Frontage Laboratories Inc. is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, among other things, or status as a qualified individual with disability.
