Research Associate

23 hours ago


Menlo Park, California, United States BillionToOne Full time
About BillionToOne

BillionToOne is a pioneering molecular diagnostics company dedicated to developing innovative and accurate diagnostic tests that transform the lives of patients worldwide. Our cutting-edge QCT molecular counting technology has revolutionized the field of disease detection, enabling us to provide unparalleled insights into the molecular mechanisms of cancer and other diseases.

Job Summary

We are seeking a highly skilled Translational Research Associate to join our Oncology Clinical Affairs team. As a key member of our team, you will play a critical role in driving clinical study analysis, from coordinating samples with our lab operations to publications. Your expertise in bioinformatics, statistics, and genomics will be instrumental in demonstrating the clinical validity of our Northstar assays, a groundbreaking liquid biopsy test that combines treatment selection with monitoring.

Responsibilities
  • Design, execute, and validate automated scripts for managing and organizing diverse data corresponding to large clinical studies, including bioinformatic next-generation sequencing (NGS) results and longitudinal clinical health records.
  • Build, maintain, and execute analytic pipelines combining molecular and clinical results, which will include data cleaning, statistical analysis, oral and written presentation of results.
  • Devise and apply appropriate statistical methods on time-series molecular and clinical measurements.
  • Collaborate with internal and external stakeholders to advance ongoing clinical studies and provide analytical insights.
  • Summarize findings orally and in writing, internally and externally.
  • Contribute to poster and publication preparation; attend conferences.
Requirements
  • Education: Bachelor's or Master's in Computer Science, Biostatistics, Statistics, or related field.
  • Experience: Bachelor's with at least 1-2 years of experience in a research or clinical setting or a Master's in a relevant field.
  • Communication: Exceptional written and verbal communication skills. Ability to work collaboratively with internal and external stakeholders with diverse specializations in business, translational research, clinical research, bioinformatics, and benchwork.
  • Technical: Proficiency in Python or R. Experience with large data sets and data pipeline engineering. Ability to efficiently retrieve, modify, merge, and summarize data from disparate sources and across a multitude of formats.
  • Statistics: Strong fundamental knowledge including hypothesis testing, statistical distributions, confounders, and multiple test correction.
  • Genetics: Conceptual understanding of somatic variation, germline variation, epigenetics, and corresponding lab technologies such as PCR and NGS.
Nice-to-Haves
  • Experience: analyzing clinical studies or clinical trials; translational cancer research; one or more peer-reviewed publications in oncology.
  • Technical: Git, GitHub, AWS, S3, SQL, Redcap, OCR, LLMs, machine learning.
  • Statistics: Kaplan Meier curves, hazard ratios, time series analysis.
  • Regulatory Knowledge: Experience in diagnostics test and/or drug regulatory approval process. Familiarity with HIPAA regulations.
  • Genetics: Familiarity with cancer biology, aneuploidy, copy number variation, circulating tumor DNA (ctDNA), cell-free DNA (cfDNA).
  • Clinical: Experience with clinical studies, RECIST, radiology, oncology, pharmacology, or pathology.
Benefits and Perks
  • Working with a team of 'rockstars' who bring out the best in everyone.
  • Open, transparent culture that includes weekly Town Hall meetings.
  • The ability to indirectly or directly change the lives of hundreds of thousands of patients.
  • Multiple medical benefit options; employee premiums paid 100% of select plans, dependents covered at 80%.
  • Extremely generous Family Bonding Leave for new parents (16 weeks, paid at 100%).
  • Retirement savings program including a 4% Company match.
  • Free daily on-site lunches provided from top eateries.
  • Latest and greatest hardware (laptop, lab equipment, facilities).
  • A variety of perks on campus (state-of-the-art gym, restaurant).
  • Free on-site EV charging (compatible with all EVs, including Tesla).
About the Role

This is a dynamic, start-up environment that requires adaptability and the ability to quickly learn and apply new concepts. The Translational Research Associate role is a hybrid position in our Menlo Park, CA facility.


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