Process Development Principal Scientist – Synthetic Peptides, Oligonucleotides, ADCs

2 weeks ago


Thousand Oaks, California, United States Amgen Full time
Job Title: Process Development Principal Scientist – Synthetic Peptides, Oligonucleotides, ADCs

Amgen is seeking a highly skilled Process Development Principal Scientist to join our Drug Substance Technologies - Synthetics (DSTS) group. As a key member of our team, you will be responsible for developing efficient and sustainable manufacturing processes for synthetic peptides, oligonucleotides, and antibody drug conjugates (ADCs).

Key Responsibilities:
  • Work with a diverse team of synthetic chemists, chemical engineers, and analytical chemists to develop sustainable and cost-effective processes for synthetic peptide, oligonucleotide, and ADC manufacturing.
  • Drive technology innovation in the synthesis, purification, and characterization of bio-conjugates.
  • Support cGMP manufacturing and technology transfer to large-scale production facilities.
  • Develop strategies to ensure process performance through process understanding, modeling, and characterization.
  • Guide successful completion of project deliverables and ensure timelines are met.
  • Work cross-functionally to deliver regulatory documents and support regulatory filings.
  • Serve as a technical expert and keep current in the field of peptide, oligonucleotide, and ADC manufacturing.
  • Coach and provide career and scientific/technical advice to colleagues within the organization.
Requirements:
  • Doctorate degree in Chemistry, Biochemistry, or Chemical Biology with 2+ years of industry experience.
  • Or Master's degree in Chemistry, Biochemistry, or Chemical Biology and 5+ years of industry experience.
  • Or Bachelor's degree and 7 years of industry experience.
  • Experience working in the pharmaceutical industry with expertise in synthetic peptide, oligonucleotide, and ADC process development and manufacturing.
  • Extensive hands-on expertise in the synthesis and purification of peptides, oligonucleotides, and ADCs and experience with bio-conjugation techniques.
  • Proficiency in analytical characterization techniques such as Hydrophobic Interaction Chromatography (HIC)-HPLC, Size Exclusion Chromatography (SEC), Liquid Chromatography–Mass Spectrometry (LC-MS), Ion-Exchange (IEX), and Reversed Phase (RP)-HPLC.
  • Demonstrated ability to work within a dynamic and interdisciplinary environment to achieve results.
  • People-centered leadership skills in building strong teams through mutual trust and respect and exhibits Amgen leadership attributes of inspire, accelerate, integrate, and adapt.
  • Proven track record of publications, patents, and presentations.


  • Thousand Oaks, California, United States Amgen Full time

    About the RoleAmgen is seeking a talented Process Development Senior Scientist to join our Drug Substance Technologies - Synthetics (DSTS) group. As a key member of our team, you will be responsible for inventing synthetic routes and developing safe, robust, and cost-effective processes to manufacture synthetic and hybrid drug substances.Key...


  • Thousand Oaks, California, United States Amgen Full time

    Job Title: Process Development Senior Principal Scientist – Peptide ChemistryAmgen is seeking a dedicated Process Development Senior Principal Scientist with industry experience in peptide synthesis and manufacturing to join our Drug Substance Technologies - Synthetics (DSTS) group in Cambridge, MA.Key Responsibilities:Lead a multidisciplinary project team...


  • Thousand Oaks, California, United States Amgen Full time

    Job Title: Process Development Principal ScientistAt Amgen, we are committed to serving patients by developing innovative treatments that improve lives. As a Process Development Principal Scientist, you will play a critical role in leading our team to achieve this mission.Job Summary:We are seeking a highly skilled and experienced Process Development...


  • Thousand Oaks, California, United States Amgen Full time

    Job Title: Process Development Principal ScientistAmgen is seeking a highly skilled Process Development Principal Scientist to join our team in Thousand Oaks, California or Cambridge, Massachusetts.Job Summary:We are looking for a talented scientist to lead the development of commercial manufacturing processes for small and hybrid molecules. As a Process...


  • Thousand Oaks, California, United States Amgen Full time

    Defy Imagination with a Career at AmgenAt Amgen, we're driven by a shared mission to serve patients. We're a global collaborator, researching, manufacturing, and delivering innovative products that reach over 10 million patients worldwide.Key Responsibilities:Provide strategic analytical leadership to teams developing commercial manufacturing processes for...


  • Thousand Oaks, California, United States Takeda Pharmaceuticals Full time

    About the RoleWe are seeking a highly skilled Principal Manufacturing Scientist to join our team at Takeda Pharmaceuticals. As a key member of our Manufacturing Sciences Department, you will play a critical role in supporting the development and implementation of manufacturing processes for our cell culture and purification operations.Key...


  • Thousand Oaks, California, United States Amgen SA Full time

    Senior Principal Scientist - PKDMAmgen is seeking a highly skilled Senior Principal Scientist to join our PKDM team. As a subject matter expert in ADME/PK, you will play a critical role in the development of small molecule therapeutic drug candidates.Key Responsibilities:Serve as a functional PKDM representative and subject matter expert on the ADME/PK of...


  • Thousand Oaks, California, United States EPM Scientific Full time

    Job Title: Principal Scientist- Drug SubstanceJob Summary: We are seeking a highly skilled Principal Scientist to join our Manufacturing Sciences Department. The successful candidate will be responsible for leading cross-functional teams to perform process optimization, technology transfer, and investigations. The ideal candidate will have a strong...


  • Thousand Oaks, California, United States Takeda Pharmaceutical Company Ltd Full time

    Job Title: Principal Manufacturing ScientistThis role is part of the Manufacturing Sciences Department, specifically supporting Cell Culture and Purification manufacturing processes. As a Principal Manufacturing Scientist, you will oversee daily manufacturing support, inter-facility, and global process alignments/improvements initiatives of commercial and...


  • Thousand Oaks, California, United States Takeda Pharmaceuticals Full time

    About the RoleWe are seeking a highly skilled Principal Manufacturing Scientist to join our Manufacturing Sciences Department. As a key member of our team, you will be responsible for supporting the development and implementation of manufacturing processes for our cell culture and purification operations.Key ResponsibilitiesLead technical and...


  • Thousand Oaks, California, United States Takeda Pharmaceutical Company Ltd Full time

    About the RoleThe Principal Manufacturing Scientist will play a key role in supporting the Manufacturing Sciences (MS) Department, specifically in Cell Culture and Purification manufacturing processes. This position will oversee daily manufacturing support, inter-facility, and global process alignments/improvements initiatives of commercial and clinical...


  • Thousand Oaks, California, United States ACL Digital Full time

    Job Title: Process Development EngineerLocation: Not SpecifiedDuration: Not SpecifiedWe are seeking a highly skilled Process Development Engineer to join our Drug Substance Technology Engineering team. The successful candidate will provide process engineering support for human therapeutic products in clinical development through commercial production.The...


  • Thousand Oaks, California, United States Belcan Full time

    Job Title: Process Development EngineerWe are seeking a highly skilled Process Development Engineer to join our team at Belcan. As a Process Development Engineer, you will be responsible for providing process engineering support for human therapeutic products in clinical development through commercial production.Our mission is to translate developmental...


  • Thousand Oaks, California, United States ACL Digital Full time

    Job Title: Downstream Process EngineerLocation: Thousand Oaks, CADuration: 12 MonthsDescription:We are seeking a highly skilled Process Development Engineer to join our Drug Substance Technology Engineering team at our Thousand Oaks facility. As a key member of our team, you will provide process engineering support for human therapeutic products in clinical...


  • Thousand Oaks, California, United States Amgen Full time

    Job Title: Director Process DevelopmentThis is a challenging and rewarding role that requires a strong background in biopharmaceutical process development. As a Director of Process Development, you will lead a team of scientists and engineers responsible for the development and implementation of biologics processes.Key Responsibilities:Lead a team of...


  • Thousand Oaks, California, United States ACL Digital Full time

    Process Development EngineerWe are seeking a highly skilled Process Development Engineer to join our Drug Substance Technology Engineering team at ACL Digital.Key Responsibilities:Provide process engineering support for human therapeutic products in clinical development through commercial production.Apply cell culture and/or purification process engineering...


  • Thousand Oaks, California, United States Infotree Global Solutions Full time

    Process Development Engineer OpportunityWe are seeking a highly skilled Process Development Engineer to join our Drug Substance Technology Engineering team at our Thousand Oaks facility.Key Responsibilities:Apply cell culture and purification process engineering knowledge to support technology transfer and clinical/commercial drug substance...


  • Thousand Oaks, California, United States US Tech Solutions Full time

    Job Title: Process Development EngineerWe are seeking a highly skilled Process Development Engineer to join our Drug Substance Technology Engineering team at our Thousand Oaks facility.The successful candidate will apply cell culture and/or purification process engineering knowledge in support of technology transfer and clinical/commercial drug substance...


  • Thousand Oaks, California, United States Analysts Full time

    Job DescriptionInnova Solutions is seeking a highly skilled Process Development Engineer to join their team. The ideal candidate will have a strong background in biologics engineering, with experience in purification processes and equipment. The successful candidate will be responsible for providing process engineering and technology transfer support for...


  • Thousand Oaks, California, United States ACL Digital Full time

    Job Title: Downstream Process EngineerLocation: Thousand Oaks, CADuration: 12 MonthsDescription:We are seeking a highly skilled Process Development Engineer to join our Drug Substance Technology Engineering team at our Thousand Oaks facility. As a key member of our team, you will provide process engineering support for human therapeutic products in clinical...